Combining Antivirals and Immunomodulators to Fight COVID-19.
Angiotensin-Converting Enzyme 2
/ immunology
Antiviral Agents
/ immunology
COVID-19
/ immunology
Cytokines
/ immunology
Humans
Immunologic Factors
/ immunology
Interferon Type I
/ immunology
SARS-CoV-2
/ drug effects
Serine Endopeptidases
/ immunology
Virus Replication
/ drug effects
COVID-19 Drug Treatment
COVID-19
IFNα/β
SARS-CoV-2
antiviral molecules
cytokine storm
immunomodulators
Journal
Trends in immunology
ISSN: 1471-4981
Titre abrégé: Trends Immunol
Pays: England
ID NLM: 100966032
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
09
06
2020
revised:
06
11
2020
accepted:
06
11
2020
pubmed:
8
12
2020
medline:
26
1
2021
entrez:
7
12
2020
Statut:
ppublish
Résumé
The majority of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected individuals remain paucisymptomatic, contrasting with a minority of infected individuals in danger of death. Here, we speculate that the robust disease resistance of most individuals is due to a swift production of type I interferon (IFNα/β), presumably sufficient to lower the viremia. A minority of infected individuals with a preexisting chronic inflammatory state fail to mount this early efficient response, leading to a delayed harmful inflammatory response. To improve the epidemiological scenario, we propose combining: (i) the development of efficient antivirals administered early enough to assist in the production of endogenous IFNα/β; (ii) potentiating early IFN responses; (iii) administering anti-inflammatory treatments when needed, but not too early to interfere with endogenous antiviral responses.
Identifiants
pubmed: 33281063
pii: S1471-4906(20)30261-1
doi: 10.1016/j.it.2020.11.003
pmc: PMC7664349
pii:
doi:
Substances chimiques
Antiviral Agents
0
Cytokines
0
Immunologic Factors
0
Interferon Type I
0
ACE2 protein, human
EC 3.4.17.23
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Serine Endopeptidases
EC 3.4.21.-
TMPRSS2 protein, human
EC 3.4.21.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
31-44Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Références
Ann N Y Acad Sci. 2010 Jan;1183:89-103
pubmed: 20146710
AIDS Res Hum Retroviruses. 1990 Apr;6(4):481-9
pubmed: 1692728
Trends Microbiol. 2001 Mar;9(3):113-4
pubmed: 11303500
JAMA. 2020 Aug 25;324(8):782-793
pubmed: 32648899
N Engl J Med. 2020 May 7;382(19):1787-1799
pubmed: 32187464
BMJ. 2020 May 14;369:m1849
pubmed: 32409561
Nat Commun. 2020 Sep 17;11(1):4682
pubmed: 32943628
Inflammation. 2016 Aug;39(4):1582-93
pubmed: 27351430
Influenza Other Respir Viruses. 2007 Sep-Nov;1(5-6):189-92
pubmed: 19453426
Antiviral Res. 2020 Jun;178:104793
pubmed: 32283108
Cell Host Microbe. 2016 Feb 10;19(2):181-93
pubmed: 26867177
J Biol Chem. 2009 Jun 12;284(24):16202-9
pubmed: 19380580
Life Sci. 2006 Apr 4;78(19):2166-71
pubmed: 16303146
Ann N Y Acad Sci. 1993 Jun 23;685:501-11
pubmed: 7689810
J Clin Invest. 2009 Dec;119(12):3544-55
pubmed: 19959873
Oncotarget. 2016 Aug 9;7(32):52294-52306
pubmed: 27418133
Ann Intern Med. 2020 Oct 20;173(8):623-631
pubmed: 32673060
BMC Med. 2020 Mar 25;18(1):81
pubmed: 32209092
PLoS Negl Trop Dis. 2010 Aug 10;4(8):e785
pubmed: 20706626
Virology. 2015 Nov;485:330-9
pubmed: 26331680
Curr Opin Virol. 2012 Jun;2(3):264-75
pubmed: 22572391
J Clin Invest. 2002 Jan;109(1):79-87
pubmed: 11781353
J Gen Virol. 2015 Dec;96(12):3484-3492
pubmed: 26459826
Front Microbiol. 2019 Jan 29;10:50
pubmed: 30761102
Annu Rev Virol. 2016 Sep 29;3(1):237-261
pubmed: 27578435
Lancet. 2020 Feb 15;395(10223):e30-e31
pubmed: 32032529
Mol Cell Biol. 2006 Mar;26(5):1888-97
pubmed: 16479007
Respir Med. 2003 Mar;97(3):250-6
pubmed: 12645832
JCI Insight. 2019 Feb 21;4(4):
pubmed: 30830861
Blood. 2001 Jul 1;98(1):146-55
pubmed: 11418474
PLoS Biol. 2008 Sep 16;6(9):e226
pubmed: 18798692
J Exp Med. 1998 Dec 21;188(12):2205-13
pubmed: 9858507
Semin Immunopathol. 2017 Jul;39(5):563-574
pubmed: 28401256
Lancet. 1981 Jun 6;1(8232):1228-31
pubmed: 6112565
Science. 2020 May 1;368(6490):473-474
pubmed: 32303591
Antibiot Chemother (Northfield). 1952 Apr;2(4):171-4
pubmed: 24541823
J Clin Invest. 2001 Jan;107(1):121-30
pubmed: 11134187
Eur J Med Chem. 2020 Sep 1;201:112527
pubmed: 32563812
Biochim Biophys Acta. 2013 Dec;1833(12):2866-2878
pubmed: 23872422
Thorax. 2004 Mar;59(3):252-6
pubmed: 14985565
PLoS Pathog. 2010 Feb 05;6(2):e1000756
pubmed: 20140198
J Virol. 2017 Mar 29;91(8):
pubmed: 28148787
Emerg Infect Dis. 2004 May;10(5):818-24
pubmed: 15200814
Vector Borne Zoonotic Dis. 2008 Dec;8(6):837-9
pubmed: 18620511
Eur J Immunol. 2005 Jan;35(1):139-49
pubmed: 15597326
J Virol. 2010 Aug;84(15):7886-91
pubmed: 20484518
Emerg Infect Dis. 2006 Jan;12(1):15-22
pubmed: 16494711
Lancet Rheumatol. 2020 Aug;2(8):e474-e484
pubmed: 32835257
Blood. 2008 Feb 1;111(3):1420-7
pubmed: 17991806
J Clin Diagn Res. 2016 Apr;10(4):OD10-1
pubmed: 27190868
Cytokine. 2015 Mar;72(1):109-12
pubmed: 25542095
J Immunol. 2004 Jun 15;172(12):7841-7
pubmed: 15187168
Elife. 2020 Jan 28;9:
pubmed: 31990272
N Engl J Med. 1998 Nov 19;339(21):1485-92
pubmed: 9819446
J Allergy Clin Immunol. 2006 Jan;117(1):111-8
pubmed: 16387593
JAMA. 2020 Jun 23;323(24):2493-2502
pubmed: 32392282
J Mol Biol. 1993 Aug 20;232(4):1069-83
pubmed: 8371267
Int J Infect Dis. 2014 Mar;20:42-6
pubmed: 24406736
Nat Rev Drug Discov. 2020 Mar;19(3):149-150
pubmed: 32127666
Clin Sci (Lond). 2016 Aug 1;130(15):1339-52
pubmed: 27129189
N Engl J Med. 2020 Dec 2;:
pubmed: 33264556
Am J Med. 1999 May;106(5):506-12
pubmed: 10335721
Proc Natl Acad Sci U S A. 1984 Nov;81(21):6733-7
pubmed: 6436820
Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14333-8
pubmed: 14612562
Science. 2020 Oct 23;370(6515):
pubmed: 32972996
Cell Host Microbe. 2017 Aug 9;22(2):176-184
pubmed: 28799903
Cytokine Growth Factor Rev. 2020 Jun;53:33-37
pubmed: 32389499
Proc Natl Acad Sci U S A. 1979 Apr;76(4):1824-7
pubmed: 287023
J Virol. 2007 Jan;81(2):548-57
pubmed: 17108024
Front Pharmacol. 2019 Mar 07;10:178
pubmed: 30930772
Travel Med Infect Dis. 2020 May - Jun;35:101738
pubmed: 32387409
Monogr Virol. 1974;8(0):1-103
pubmed: 4367453
Lancet Rheumatol. 2020 Jul;2(7):e393-e400
pubmed: 32835245
Atherosclerosis. 2018 Feb;269:262-271
pubmed: 29352570
Cell Death Differ. 2020 Nov;27(11):3196-3207
pubmed: 32514047
Nat Rev Microbiol. 2009 Jun;7(6):439-50
pubmed: 19430490
Microbiol Mol Biol Rev. 2012 Mar;76(1):16-32
pubmed: 22390970
N Engl J Med. 1986 Aug 7;315(6):341-7
pubmed: 2426590
Trends Microbiol. 2015 Mar;23(3):172-80
pubmed: 25572882
Med Res Rev. 2020 Sep;40(5):1519-1557
pubmed: 32060956
Biochimie. 2007 Jun-Jul;89(6-7):878-83
pubmed: 17561326
Nature. 2020 Dec;588(7836):146-150
pubmed: 32726800
Virology. 2020 Sep;548:1-5
pubmed: 32530808
Lancet. 2020 Feb 15;395(10223):473-475
pubmed: 32043983
Antiviral Res. 2015 Mar;115:9-16
pubmed: 25542975
Nature. 2020 Sep;585(7826):584-587
pubmed: 32698191
Science. 2001 Jan 19;291(5503):484-6
pubmed: 11161202
mBio. 2017 Nov 21;8(6):
pubmed: 29162711
J Virol. 2013 May;87(9):5300-4
pubmed: 23449793
J Interferon Cytokine Res. 2018 Feb;38(2):69-80
pubmed: 29443656
Proc Jpn Acad Ser B Phys Biol Sci. 2017;93(7):449-463
pubmed: 28769016
Proteomics. 2012 Nov;12(21):3193-205
pubmed: 22936401
BMJ. 2020 Oct 22;371:m3939
pubmed: 33093056
J Rheumatol. 2013 Jun;40(6):831-41
pubmed: 23588942
Nat Immunol. 2013 May;14(5):454-60
pubmed: 23502856
Cell. 2020 May 28;181(5):1036-1045.e9
pubmed: 32416070
Nat Commun. 2019 Sep 11;10(1):4131
pubmed: 31511510
Cytokine. 2003 Jun 21;22(6):198-205
pubmed: 12890453
J Virol. 2007 Nov;81(21):11620-33
pubmed: 17715225
J Autoimmun. 2020 Jul;111:102468
pubmed: 32317220
Antimicrob Agents Chemother. 2002 Apr;46(4):977-81
pubmed: 11897578
Eur J Immunol. 1993 Sep;23(9):2375-8
pubmed: 8370415
Am J Trop Med Hyg. 1955 Mar;4(2):221-3
pubmed: 14361900
Ann N Y Acad Sci. 2000 Jun;908:244-54
pubmed: 10911963
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Methods Mol Biol. 2015;1282:1-23
pubmed: 25720466
Cell Host Microbe. 2020 Jun 10;27(6):992-1000.e3
pubmed: 32320677
Springer Semin Immunopathol. 2006 Jun;27(4):391-408
pubmed: 16738952
N Engl J Med. 2020 Jul 17;:
pubmed: 32678530
Clin Infect Dis. 2008 Feb 1;46(3):402-12
pubmed: 18181739
Expert Opin Drug Saf. 2011 May;10(3):429-35
pubmed: 21323500
Sci Rep. 2015 Dec 03;5:17554
pubmed: 26631542
Nature. 2020 Jul;583(7816):459-468
pubmed: 32353859
Nat Med. 2018 Jun;24(6):739-748
pubmed: 29808007
Science. 2020 Aug 7;369(6504):718-724
pubmed: 32661059
J Gen Virol. 2010 Mar;91(Pt 3):765-72
pubmed: 19889926
Lancet Infect Dis. 2014 Nov;14(11):1090-1095
pubmed: 25278221
J Virol. 2014 May;88(9):4866-76
pubmed: 24522921
Antimicrob Agents Chemother. 2020 Aug 20;64(9):
pubmed: 32661006
Curr Top Med Chem. 2010;10(3):323-45
pubmed: 20166951