Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines.
Amino Acid Sequence
Bacteria
/ genetics
Biocatalysis
Biological Products
/ chemistry
Crystallography, X-Ray
Cytochrome P-450 Enzyme System
/ chemistry
Diketopiperazines
/ chemistry
Dimerization
Molecular Dynamics Simulation
Molecular Structure
Protein Domains
Sequence Homology, Amino Acid
Stereoisomerism
Substrate Specificity
Tryptophan
/ chemistry
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
07 12 2020
07 12 2020
Historique:
received:
19
06
2020
accepted:
03
11
2020
entrez:
8
12
2020
pubmed:
9
12
2020
medline:
29
12
2020
Statut:
epublish
Résumé
Bacterial heterodimeric tryptophan-containing diketopiperazines (HTDKPs) are a growing family of bioactive natural products. They are challenging to prepare by chemical routes due to the polycyclic and densely functionalized backbone. Through functional characterization and investigation, we herein identify a family of three related HTDKP-forming cytochrome P450s (NasbB, Nas
Identifiants
pubmed: 33288748
doi: 10.1038/s41467-020-20022-5
pii: 10.1038/s41467-020-20022-5
pmc: PMC7721796
doi:
Substances chimiques
Biological Products
0
Diketopiperazines
0
Tryptophan
8DUH1N11BX
Cytochrome P-450 Enzyme System
9035-51-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6251Références
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