DNase-mediated eDNA removal enhances D-LL-31 activity against biofilms of bacteria isolated from chronic rhinosinusitis patients.

Anti-Bacterial Agents Bacteria / genetics Biofilms Deoxyribonuclease I Deoxyribonucleases
Bactericidal activity D-LL-31 D-enantiomer peptide DNase I chronic rhinosinusitis eDNA

Journal

Biofouling
ISSN: 1029-2454
Titre abrégé: Biofouling
Pays: England
ID NLM: 9200331

Informations de publication

Date de publication:
10 2020
Historique:
pubmed: 11 12 2020
medline: 2 3 2021
entrez: 10 12 2020
Statut: ppublish

Résumé

Chronic rhinosinusitis (CRS) is a chronic infection of the nasal cavity and paranasal sinuses associated with the presence of a microbial biofilm. Extracellular DNA (eDNA) is an important component of the biofilm matrix. Antimicrobial peptides (AMPs) are natural peptides with the ability to kill microorganisms. D-LL-31 is a synthetic variant of the AMP cathelicidin with increased resistance to proteolytic breakdown. In this study it is shown for 3 clinical CRS isolates that treatment of 24 h biofilms with DNase I enhanced the antimicrobial activity of D-LL-31. Conversely, co-incubation of D-LL-31 at the IC

Identifiants

DOI: 10.1080/08927014.2020.1857741 PMID: 33297738
pubmed: 33297738
doi: 10.1080/08927014.2020.1857741
doi:

Substances chimiques

Anti-Bacterial Agents 0
Deoxyribonucleases EC 3.1.-
Deoxyribonuclease I EC 3.1.21.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1117-1128

Auteurs

Saharut Wongkaewkhiaw (S)

Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Sakawrat Kanthawong (S)

Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Biofilm Research Group, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand.

Jan G M Bolscher (JGM)

Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Kamran Nazmi (K)

Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Suwimol Taweechaisupapong (S)

Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Biofilm Research Group, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand.

Bastiaan P Krom (BP)

Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › DNase-mediated eDNA removal enhances D-LL-31...
questionsmedicales.fr › Bactéries › DNase-mediated eDNA removal enhances D-LL-31...
questionsmedicales.fr › Phénomènes microbiologiques › Biofilms › DNase-mediated eDNA removal enhances D-LL-31...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Désoxyribonucléases › Deoxyribonuclease I › DNase-mediated eDNA removal enhances D-LL-31...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Désoxyribonucléases › DNase-mediated eDNA removal enhances D-LL-31...