Chemical Modulators of Fibrinogen Production and Their Impact on Venous Thrombosis.
Animals
Animals, Genetically Modified
Anthralin
/ pharmacology
Blood Coagulation
/ drug effects
Disease Models, Animal
Fibrinogen
/ genetics
Fibrinolytic Agents
/ pharmacology
Hep G2 Cells
Hepatocytes
/ drug effects
Humans
Integrin alpha2
/ genetics
Morpholinos
/ pharmacology
Mutation
Oligonucleotides, Antisense
/ pharmacology
Proteomics
Small Molecule Libraries
Tretinoin
/ pharmacology
Venous Thrombosis
/ drug therapy
Zebrafish
/ genetics
Zebrafish Proteins
/ genetics
Journal
Thrombosis and haemostasis
ISSN: 2567-689X
Titre abrégé: Thromb Haemost
Pays: Germany
ID NLM: 7608063
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
pubmed:
11
12
2020
medline:
16
11
2021
entrez:
10
12
2020
Statut:
ppublish
Résumé
Thrombosis is a leading cause of morbidity and mortality. Fibrinogen, the soluble substrate for fibrin-based clotting, has a central role in haemostasis and thrombosis and its plasma concentration correlates with cardiovascular disease event risk and a prothrombotic state in experimental models. We aimed to identify chemical entities capable of changing fibrinogen production and test their impact on experimental thrombosis. A total of 1,280 bioactive compounds were screened for their ability to alter fibrinogen production by hepatocyte-derived cancer cells and a selected panel was tested in zebrafish larvae. Anthralin and all-
Identifiants
pubmed: 33302304
doi: 10.1055/s-0040-1718414
pmc: PMC7982297
doi:
Substances chimiques
Fibrinolytic Agents
0
Integrin alpha2
0
Morpholinos
0
Oligonucleotides, Antisense
0
Small Molecule Libraries
0
Zebrafish Proteins
0
Tretinoin
5688UTC01R
Fibrinogen
9001-32-5
Anthralin
U8CJK0JH5M
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
433-448Subventions
Organisme : #31003A_152633
ID : Swiss National Science Foundation
Commentaires et corrections
Type : CommentIn
Informations de copyright
Thieme. All rights reserved.
Déclaration de conflit d'intérêts
R. J. Fish has received travel support from Novo Nordisk. All other authors have no conflict of interest to declare.
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