Tibialis anterior electromyographic bursts during sleep in histamine-deficient mice.
animal models
hypothalamus
inter-movement interval
short-interval leg movements during sleep
tuberomammillary nucleus
Journal
Journal of sleep research
ISSN: 1365-2869
Titre abrégé: J Sleep Res
Pays: England
ID NLM: 9214441
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
02
10
2020
received:
06
06
2020
accepted:
18
11
2020
pubmed:
15
12
2020
medline:
29
9
2021
entrez:
14
12
2020
Statut:
ppublish
Résumé
Antihistamine medications have been suggested to elicit clinical features of restless legs syndrome. The available data are limited, particularly concerning periodic leg movements during sleep, which are common in restless legs syndrome and involve bursts of tibialis anterior electromyogram. Here, we tested whether the occurrence of tibialis anterior electromyogram bursts during non-rapid eye movement sleep is altered in histidine decarboxylase knockout mice with congenital histamine deficiency compared with that in wild-type control mice. We implanted six histidine decarboxylase knockout and nine wild-type mice to record neck muscle electromyogram, bilateral tibialis anterior electromyogram, and electroencephalogram during the rest (light) period. The histidine decarboxylase knockout and wild-type mice did not differ significantly in terms of sleep architecture. In both histidine decarboxylase knockout and wild-type mice, the distribution of intervals between tibialis anterior electromyogram bursts had a single peak for intervals < 10 s. The total occurrence rate of tibialis anterior electromyogram bursts during non-rapid eye movement sleep and the occurrence rate of the tibialis anterior electromyogram bursts separated by intervals < 10 s were significantly lower in histidine decarboxylase knockout than in wild-type mice. These data do not support the hypothesis that preventing brain histamine signalling may promote restless legs syndrome. Rather, the data suggest that limb movements during sleep, including those separated by short intervals, are a manifestation of subcortical arousal requiring the integrity of brain histamine signalling.
Substances chimiques
Histamine
820484N8I3
Histidine Decarboxylase
EC 4.1.1.22
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13255Informations de copyright
© 2020 European Sleep Research Society.
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