Targeting Opposing Immunological Roles of the Junctional Adhesion Molecule-A in Autoimmunity and Cancer.
F11 receptor
autoimmune diseases
cell adhesion
epithelial barrier
inflammation
junctional adhesion molecule-A
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
02
09
2020
accepted:
02
11
2020
entrez:
16
12
2020
pubmed:
17
12
2020
medline:
22
6
2021
Statut:
epublish
Résumé
The junctional adhesion molecule-A (JAM-A) is a cell surface adhesion molecule expressed on platelets, epithelial cells, endothelial cells and leukocytes (e. g. monocytes and dendritic cells). JAM-A plays a relevant role in leukocyte trafficking and its therapeutic potential has been studied in several pathological conditions due to its capacity to induce leukocyte migration out of inflamed sites or infiltration into tumor sites. However, disruption of JAM-A pathways may worsen clinical pathology in some cases. As such, the effects of JAM-A manipulation on modulating immune responses in the context of different diseases must be better understood. In this mini-review, we discuss the potential of JAM-A as a therapeutic target, summarizing findings from studies manipulating JAM-A in the context of inflammatory diseases (e.g. autoimmune diseases) and cancer and highlighting described mechanisms.
Identifiants
pubmed: 33324419
doi: 10.3389/fimmu.2020.602094
pmc: PMC7723963
doi:
Substances chimiques
Inflammation Mediators
0
Junctional Adhesion Molecule A
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
602094Subventions
Organisme : Versus Arthritis
ID : 19788
Pays : United Kingdom
Organisme : Arthritis Research UK
ID : 19788
Pays : United Kingdom
Informations de copyright
Copyright © 2020 Bonilha, Benson, Brewer and Garside.
Déclaration de conflit d'intérêts
Author RB was employed by the company Antibody Analytics Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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