Micronucleus frequency in buccal mucosa cells of patients with neurodegenerative diseases.
Aged
Aged, 80 and over
DNA Damage
Disease Susceptibility
Epithelial Cells
/ metabolism
Female
Genetic Markers
Genetic Predisposition to Disease
Humans
Life Style
Male
Micronuclei, Chromosome-Defective
Micronucleus Tests
Middle Aged
Mouth Mucosa
/ metabolism
Neurodegenerative Diseases
/ etiology
Risk Assessment
Risk Factors
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
17 12 2020
17 12 2020
Historique:
received:
07
02
2020
accepted:
26
11
2020
entrez:
18
12
2020
pubmed:
19
12
2020
medline:
11
5
2021
Statut:
epublish
Résumé
Neurodegenerative diseases show an increase in prevalence and incidence, with the most prominent example being Alzheimer's disease. DNA damage has been suggested to play a role in the pathogenesis, but the exact mechanisms remain elusive. We enrolled 425 participants with and without neurodegenerative diseases and analyzed DNA damage in the form of micronuclei in buccal mucosa samples. In addition, other parameters such as binucleated cells, karyolytic cells, and karyorrhectic cells were quantified. No relevant differences in DNA damage and cytotoxicity markers were observed in patients compared to healthy participants. Furthermore, other parameters such as lifestyle factors and diseases were also investigated. Overall, this study could not identify a direct link between changes in buccal cells and neurogenerative diseases, but highlights the influence of lifestyle factors and diseases on the human buccal cytome.
Identifiants
pubmed: 33335130
doi: 10.1038/s41598-020-78832-y
pii: 10.1038/s41598-020-78832-y
pmc: PMC7747561
doi:
Substances chimiques
Genetic Markers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
22196Références
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