Chemical genetic approach using β-rubromycin reveals that a RIO kinase-like protein is involved in morphological development in Phytophthora infestans.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
18 12 2020
18 12 2020
Historique:
received:
25
02
2020
accepted:
08
12
2020
entrez:
19
12
2020
pubmed:
20
12
2020
medline:
29
4
2021
Statut:
epublish
Résumé
To characterize the molecular mechanisms underlying life-stage transitions in Phytophthora infestans, we initiated a chemical genetics approach by screening for a stage-specific inhibitor of morphological development from microbial culture extracts prepared mostly from actinomycetes from soil in Japan. Of the more than 700 extracts, one consistently inhibited Ph. infestans cyst germination. Purification and identification of the active compound by ESI-MS,
Identifiants
pubmed: 33339950
doi: 10.1038/s41598-020-79326-7
pii: 10.1038/s41598-020-79326-7
pmc: PMC7749174
doi:
Substances chimiques
Quinones
0
beta-rubromycin
27267-70-5
Protein Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
22326Références
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