Genomic epidemiology reveals multiple introductions of SARS-CoV-2 from mainland Europe into Scotland.
Journal
Nature microbiology
ISSN: 2058-5276
Titre abrégé: Nat Microbiol
Pays: England
ID NLM: 101674869
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
23
06
2020
accepted:
20
11
2020
entrez:
22
12
2020
pubmed:
23
12
2020
medline:
14
1
2021
Statut:
ppublish
Résumé
Coronavirus disease 2019 (COVID-19) was first diagnosed in Scotland on 1 March 2020. During the first month of the outbreak, 2,641 cases of COVID-19 led to 1,832 hospital admissions, 207 intensive care admissions and 126 deaths. We aimed to identify the source and number of introductions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into Scotland using a combined phylogenetic and epidemiological approach. Sequencing of 1,314 SARS-CoV-2 viral genomes from available patient samples enabled us to estimate that SARS-CoV-2 was introduced to Scotland on at least 283 occasions during February and March 2020. Epidemiological analysis confirmed that early introductions of SARS-CoV-2 originated from mainland Europe (the majority from Italy and Spain). We identified subsequent early outbreaks in the community, within healthcare facilities and at an international conference. Community transmission occurred after 2 March, 3 weeks before control measures were introduced. Earlier travel restrictions or quarantine measures, both locally and internationally, would have reduced the number of COVID-19 cases in Scotland. The risk of multiple reintroduction events in future waves of infection remains high in the absence of population immunity.
Identifiants
pubmed: 33349681
doi: 10.1038/s41564-020-00838-z
pii: 10.1038/s41564-020-00838-z
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
112-122Subventions
Organisme : Wellcome Trust
ID : 201492/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19026
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L015080/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204802/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19027
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206298/Z/17/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12014/10
Pays : United Kingdom
Commentaires et corrections
Type : ErratumIn
Type : ErratumIn
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