The VP1u of Human Parvovirus B19: A Multifunctional Capsid Protein with Biotechnological Applications.


Journal

Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722

Informations de publication

Date de publication:
18 12 2020
Historique:
received: 02 12 2020
revised: 15 12 2020
accepted: 16 12 2020
entrez: 23 12 2020
pubmed: 24 12 2020
medline: 12 1 2021
Statut: epublish

Résumé

The viral protein 1 unique region (VP1u) of human parvovirus B19 (B19V) is a multifunctional capsid protein with essential roles in virus tropism, uptake, and subcellular trafficking. These functions reside on hidden protein domains, which become accessible upon interaction with cell membrane receptors. A receptor-binding domain (RBD) in VP1u is responsible for the specific targeting and uptake of the virus exclusively into cells of the erythroid lineage in the bone marrow. A phospholipase A

Identifiants

pubmed: 33352888
pii: v12121463
doi: 10.3390/v12121463
pmc: PMC7765992
pii:
doi:

Substances chimiques

Capsid Proteins 0
Immunodominant Epitopes 0
Nuclear Localization Signals 0
Receptors, Virus 0
capsid protein VP1, parvovirus B19 0
Phospholipases A2 EC 3.1.1.4

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Carlos Ros (C)

Department of Chemistry and Biochemistry, University of Bern, 3012 Bern, Switzerland.

Jan Bieri (J)

Department of Chemistry and Biochemistry, University of Bern, 3012 Bern, Switzerland.

Remo Leisi (R)

Department of Chemistry and Biochemistry, University of Bern, 3012 Bern, Switzerland.

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