Effect of Acrylamide Supplementation on the Population of Vasoactive Intestinal Peptide (VIP)-Like Immunoreactive Neurons in the Porcine Small Intestine.
acrylamide
enteric nervous system
pig
small intestine
vasoactive intestinal peptide
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
18 Dec 2020
18 Dec 2020
Historique:
received:
03
11
2020
revised:
08
12
2020
accepted:
16
12
2020
entrez:
23
12
2020
pubmed:
24
12
2020
medline:
19
3
2021
Statut:
epublish
Résumé
Acrylamide is one of the harmful substances present in food. The present study aimed to establish the effect of acrylamide supplementation in tolerable daily intake (TDI) dose (0.5 µg/kg b.w./day) and a dose ten times higher than TDI (5 µg/kg b.w./day) on the population of vasoactive intestinal peptide-like immunoreactive (VIP-LI) neurons in the porcine small intestine and the degree of the co-localization of VIP with other neuroactive substances (neuronal nitric oxide synthase (nNOS), substance P (SP), and cocaine- and amphetamine-regulated transcript peptide (CART)). In our work, 15 Danish landrace gilts (5 in each experimental group) received capsules (empty or with low or high doses of acrylamide) for a period of 28 days with their morning feeding. Using double immunofluorescence staining, we established that acrylamide supplementation increased the number of neurons showing immunoreactivity towards VIP in all types of enteric nervous system (ENS) plexuses and fragments of the small intestine studied. Moreover, both doses of acrylamide led to changes in the degree of co-localization of VIP with nNOS, SP, and CART in intramural neurons. The observed changes may be the adaptation of neurons to local inflammation, oxidative stress, or the direct toxic effects of acrylamide on intestinal neurons, also referred to as neuronal plasticity.
Identifiants
pubmed: 33353157
pii: ijms21249691
doi: 10.3390/ijms21249691
pmc: PMC7765847
pii:
doi:
Substances chimiques
Nerve Tissue Proteins
0
Acrylamide
20R035KLCI
Substance P
33507-63-0
Vasoactive Intestinal Peptide
37221-79-7
Nitric Oxide Synthase Type I
EC 1.14.13.39
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministerstwo Nauki i Szkolnictwa Wyższego
ID : No. 05-1/KNOW2/2015
Organisme : Uniwersytet Warmińsko-Mazurski w Olsztynie
ID : No 15.610.003-300
Organisme : Ministerstwo Nauki i Szkolnictwa Wyższego
ID : No. 010/RID/2018/19
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