Kidney re-transplantation in a child across the barrier of persisting angiotensin II type I receptor antibodies.


Journal

Pediatric nephrology (Berlin, Germany)
ISSN: 1432-198X
Titre abrégé: Pediatr Nephrol
Pays: Germany
ID NLM: 8708728

Informations de publication

Date de publication:
03 2021
Historique:
received: 03 09 2020
accepted: 26 11 2020
revised: 25 10 2020
pubmed: 24 12 2020
medline: 16 12 2021
entrez: 23 12 2020
Statut: ppublish

Résumé

Approximately 20% of antibody-mediated rejection (ABMR) episodes in the absence of donor-specific antibodies against human leucocyte antigens (HLA-DSA) in pediatric and adult kidney transplant recipients are associated with, and presumably caused by, antibodies against the angiotensin type 1 receptor (AT We report on a male patient with kidney failure in infancy due to obstructive uropathy who had lost his first kidney transplant due to AT This case highlights the difficulty of persistently decreasing elevated AT

Sections du résumé

BACKGROUND
Approximately 20% of antibody-mediated rejection (ABMR) episodes in the absence of donor-specific antibodies against human leucocyte antigens (HLA-DSA) in pediatric and adult kidney transplant recipients are associated with, and presumably caused by, antibodies against the angiotensin type 1 receptor (AT
CASE
We report on a male patient with kidney failure in infancy due to obstructive uropathy who had lost his first kidney transplant due to AT
CONCLUSION
This case highlights the difficulty of persistently decreasing elevated AT

Identifiants

pubmed: 33355703
doi: 10.1007/s00467-020-04879-8
pii: 10.1007/s00467-020-04879-8
pmc: PMC7851028
doi:

Substances chimiques

Antibodies 0
HLA Antigens 0
Receptor, Angiotensin, Type 1 0
Angiotensin II 11128-99-7

Types de publication

Case Reports Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

725-729

Références

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Auteurs

Annika Gold (A)

Department of Pediatrics I, University Children's Hospital Heidelberg, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany. annika.gold@med.uni-heidelberg.de.

Alexander Fichtner (A)

Department of Pediatrics I, University Children's Hospital Heidelberg, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.

Daniela Choukair (D)

Department of Pediatrics I, University Children's Hospital Heidelberg, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.

Claus Peter Schmitt (CP)

Department of Pediatrics I, University Children's Hospital Heidelberg, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.

Caner Süsal (C)

Institute of Immunology, University Hospital Heidelberg, Heidelberg, Germany.

Duska Dragun (D)

Clinic for Nephrology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Berlin Institute of Health, Berlin, Germany.

Burkhard Tönshoff (B)

Department of Pediatrics I, University Children's Hospital Heidelberg, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.

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Classifications MeSH