Lipid-protein forces predict conformational changes in a mechanosensitive channel.
Conformational change
Force distribution analysis
Functional mode analysis
Ion channel
Membrane tension
Journal
European biophysics journal : EBJ
ISSN: 1432-1017
Titre abrégé: Eur Biophys J
Pays: Germany
ID NLM: 8409413
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
30
07
2020
accepted:
01
12
2020
revised:
27
11
2020
pubmed:
24
12
2020
medline:
30
10
2021
entrez:
23
12
2020
Statut:
ppublish
Résumé
The mechanosensitive TREK-2 potassium channel, a member of the K2P family, has essential physiological roles and is, therefore, a pharmaceutical target. A combination of experimental and computational studies have established that of the two known conformations, "up" and "down", membrane tension directly favors the "up" state, which displays a higher conductance. However, these studies did not reveal the exact mechanism by which the membrane affects the channel conformation. In this work, we show that changes in protein-lipid interaction patterns suffice in predicting this conformational change, and pinpoint potentially important residues involved in this phenomenon.
Identifiants
pubmed: 33355710
doi: 10.1007/s00249-020-01488-z
pii: 10.1007/s00249-020-01488-z
pmc: PMC8071793
doi:
Substances chimiques
Membrane Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
181-186Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB803 A03
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