Lack of astrocytes hinders parenchymal oligodendrocyte precursor cells from reaching a myelinating state in osmolyte-induced demyelination.
Adult
Aged
Animals
Antidiuretic Agents
Astrocytes
/ pathology
Cell Differentiation
Cell Lineage
Deamino Arginine Vasopressin
Demyelinating Diseases
/ metabolism
Disease Models, Animal
Female
Humans
Lateral Ventricles
/ cytology
Male
Middle Aged
Myelin Sheath
Myelinolysis, Central Pontine
/ chemically induced
Neoplasm Proteins
/ metabolism
Nestin
/ metabolism
Neural Stem Cells
Oligodendrocyte Precursor Cells
/ metabolism
Oligodendroglia
/ metabolism
Rats
Sodium Chloride
Astrocytes
Multiple sclerosis
Neural stem cells
Oligodendrocyte precursor cells
Remyelination
Journal
Acta neuropathologica communications
ISSN: 2051-5960
Titre abrégé: Acta Neuropathol Commun
Pays: England
ID NLM: 101610673
Informations de publication
Date de publication:
24 12 2020
24 12 2020
Historique:
received:
11
12
2020
accepted:
13
12
2020
entrez:
28
12
2020
pubmed:
29
12
2020
medline:
10
11
2021
Statut:
epublish
Résumé
Demyelinated lesions in human pons observed after osmotic shifts in serum have been referred to as central pontine myelinolysis (CPM). Astrocytic damage, which is prominent in neuroinflammatory diseases like neuromyelitis optica (NMO) and multiple sclerosis (MS), is considered the primary event during formation of CPM lesions. Although more data on the effects of astrocyte-derived factors on oligodendrocyte precursor cells (OPCs) and remyelination are emerging, still little is known about remyelination of lesions with primary astrocytic loss. In autopsy tissue from patients with CPM as well as in an experimental model, we were able to characterize OPC activation and differentiation. Injections of the thymidine-analogue BrdU traced the maturation of OPCs activated in early astrocyte-depleted lesions. We observed rapid activation of the parenchymal NG2
Identifiants
pubmed: 33357244
doi: 10.1186/s40478-020-01105-2
pii: 10.1186/s40478-020-01105-2
pmc: PMC7761156
doi:
Substances chimiques
Antidiuretic Agents
0
BCAS1 protein, human
0
Bcas1 protein, mouse
0
Neoplasm Proteins
0
Nestin
0
Sodium Chloride
451W47IQ8X
Deamino Arginine Vasopressin
ENR1LLB0FP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
224Références
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