CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci.

Chromosome Mapping / methods Cyclin-Dependent Kinase 8 / genetics Humans Interleukin-6 / metabolism Phosphorylation STAT3 Transcription Factor / metabolism Signal Transduction

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
22 12 2020
Historique:
received: 08 06 2020
revised: 28 09 2020
accepted: 30 11 2020
entrez: 28 12 2020
pubmed: 29 12 2020
medline: 22 12 2021
Statut: ppublish

Résumé

Cytokines are highly pleiotropic ligands that regulate the immune response. Here, using interleukin-6 (IL-6) as a model system, we perform detailed phosphoproteomic and transcriptomic studies in human CD4

Identifiants

DOI: 10.1016/j.celrep.2020.108545 PMID: 33357429 PMC: PMC7773550
pubmed: 33357429
pii: S2211-1247(20)31534-5
doi: 10.1016/j.celrep.2020.108545
pmc: PMC7773550
pii:
doi:

Substances chimiques

Interleukin-6 0
STAT3 Transcription Factor 0
STAT3 protein, human 0
CDK8 protein, human EC 2.7.11.22
Cyclin-Dependent Kinase 8 EC 2.7.11.22

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108545

Subventions

Organisme : NHLBI NIH HHS
ID : K22 HL125593
Pays : United States
Organisme : Wellcome Trust
ID : 202323/Z/16/Z
Pays : United Kingdom

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

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Auteurs

Jonathan Martinez-Fabregas (J)

Division of Cell Signaling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK.

Luopin Wang (L)

Department of Computer Science, Purdue University, West Lafayette, IN, USA.

Elizabeth Pohler (E)

Division of Cell Signaling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK.

Adeline Cozzani (A)

Université de Lille, INSERM UMR1277 CNRS UMR9020-CANTHER and Institut pour la Recherche sur le Cancer de Lille (IRCL), Lille, France.

Stephan Wilmes (S)

Division of Cell Signaling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK.

Majid Kazemian (M)

Department of Computer Science, Purdue University, West Lafayette, IN, USA; Department of Biochemistry, Purdue University, West Lafayette, IN, USA. Electronic address: kazemian@purdue.edu.

Suman Mitra (S)

Université de Lille, INSERM UMR1277 CNRS UMR9020-CANTHER and Institut pour la Recherche sur le Cancer de Lille (IRCL), Lille, France. Electronic address: suman.mitra@inserm.fr.

Ignacio Moraga (I)

Division of Cell Signaling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK. Electronic address: imoragagonzalez@dundee.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Cartographie chromosomique › CDK8 Fine-Tunes IL-6 Transcriptional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Complexe médiateur › Cyclin-Dependent Kinase 8 › CDK8 Fine-Tunes IL-6 Transcriptional...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › CDK8 Fine-Tunes IL-6 Transcriptional...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-6 › CDK8 Fine-Tunes IL-6 Transcriptional...
questionsmedicales.fr › Métabolisme › Phosphorylation › CDK8 Fine-Tunes IL-6 Transcriptional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription STAT › Facteur de transcription STAT-3 › CDK8 Fine-Tunes IL-6 Transcriptional...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › CDK8 Fine-Tunes IL-6 Transcriptional...