Polyoxygenated germacranes from Daucus carota and their antimalarial transmission blocking activity.
African flora
Antimalarial activity
Apiaceae
Daucus carota
Elemane
Polyoxygenated germacranes
Journal
Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
02
10
2020
revised:
08
12
2020
accepted:
17
12
2020
pubmed:
29
12
2020
medline:
17
2
2021
entrez:
28
12
2020
Statut:
ppublish
Résumé
Chemical analysis of the aerial parts obtained from a Tunisian specimen of Daucus carota yielded to the isolation of six undescribed polyoxygenated germacranes and one elemanolide, along with one known metabolite. The stereostructures of the undescribed compounds were determined by extensive spectroscopic analysis including 1D and 2D NMR and HR-ESI-MS analysis. Due to their structural similarity with the Plasmodium transmission-blocking agent daucovirgolide G, the isolated metabolites were evaluated for their inhibitory activity on the development of Plasmodium early sporogonic stages. Three compounds proved to inhibit ookinete formation showing a good transmission blocking efficacy, but the low potency exhibited by these compounds when compared to daucovirgolide G further supports the observation that strict structural requirements do exist for the antimalarial activity of germacranolides.
Identifiants
pubmed: 33360528
pii: S0031-9422(20)31247-4
doi: 10.1016/j.phytochem.2020.112632
pii:
doi:
Substances chimiques
Antimalarials
0
Sesquiterpenes, Germacrane
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112632Subventions
Organisme : Medical Research Council
ID : MR/N00227X/1
Pays : United Kingdom
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.