L-type voltage-gated calcium channel agonists mitigate hearing loss and modify ribbon synapse morphology in the zebrafish model of Usher syndrome type 1.

Animals Calcium Channels, L-Type / metabolism Disease Models, Animal Eye Proteins / metabolism Guanylate Kinases / metabolism Hair Cells, Auditory / metabolism Hearing Loss / complications Larva / metabolism Mechanotransduction, Cellular Mutation / genetics Myosins / genetics Reflex, Startle Stereocilia / pathology Swimming Synapses / pathology Usher Syndromes / complications Zebrafish / physiology Zebrafish Proteins / genetics
Hair cell Hearing loss Ribbon synapse Zebrafish myo7aa

Journal

Disease models & mechanisms
ISSN: 1754-8411
Titre abrégé: Dis Model Mech
Pays: England
ID NLM: 101483332

Informations de publication

Date de publication:
27 11 2020
Historique:
received: 16 12 2019
accepted: 15 09 2020
entrez: 28 12 2020
pubmed: 29 12 2020
medline: 9 10 2021
Statut: epublish

Résumé

The

Identifiants

DOI: 10.1242/dmm.043885 PMID: 33361086 PMC: PMC7710014
pubmed: 33361086
pii: 13/11/dmm043885
doi: 10.1242/dmm.043885
pmc: PMC7710014
pii:
doi:

Substances chimiques

Calcium Channels, L-Type 0
Eye Proteins 0
Myo7aa protein, zebrafish 0
Zebrafish Proteins 0
ctbp2a protein, zebrafish 0
Guanylate Kinases EC 2.7.4.8
Myosins EC 3.6.4.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS094176
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000135
Pays : United States

Informations de copyright

© 2020. Published by The Company of Biologists Ltd.

Déclaration de conflit d'intérêts

Competing InterestsThe content of this article is solely the responsibility of the authors and does not necessarily represent the official view of the National Institutes of Health.

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Auteurs

Alaa Koleilat (A)

College of Continuing and Professional Studies, University of Minnesota, Minneapolis, MN 55108, USA.
Mayo Clinic Graduate School of Biomedical Sciences, Clinical and Translational Science Track, Rochester, MN 55905, USA.
Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN 55905, USA.
ORCID: 0000-0001-7949-7205

Joseph A Dugdale (JA)

Department of Otorhinolaryngology, Mayo Clinic, Rochester, MN 55905, USA.

Trace A Christenson (TA)

Mayo Clinic Microscopy and Cell Analysis Core, Rochester, MN 55905, USA.

Jeffrey L Bellah (JL)

Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN 55905, USA.
Department of Genetics and Development, Columbia University, New York City, NY 10032, USA.

Aaron M Lambert (AM)

Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

Mark A Masino (MA)

Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.

Stephen C Ekker (SC)

Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN 55905, USA.
Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA.
ORCID: 0000-0003-0726-4212

Lisa A Schimmenti (LA)

Department of Otorhinolaryngology, Mayo Clinic, Rochester, MN 55905, USA schimmenti.lisa@mayo.edu.
Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA.
Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.
Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA.
Department of Ophthalmology and Visual Neuroscience, University of Minnesota, Minneapolis, MN 55454, USA.
Department of Clinical Genomics, Mayo Clinic, Rochester, MN 55905, USA.
ORCID: 0000-0003-3154-4249

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › L-type voltage-gated calcium channel agonists...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › Canaux calciques de type L › L-type voltage-gated calcium channel agonists...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › L-type voltage-gated calcium channel agonists...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de l'oeil › L-type voltage-gated calcium channel agonists...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Phosphate Group Acceptor) › Guanylate kinase › L-type voltage-gated calcium channel agonists...
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Cellules réceptrices sensorielles › Mécanorécepteurs › Cellules neuroépithéliales › Cellules ciliées auditives › L-type voltage-gated calcium channel agonists...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Troubles sensitifs › Troubles de l'audition › Perte d'audition › L-type voltage-gated calcium channel agonists...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Morphogenèse › Métamorphose biologique › Étapes du cycle de vie › Larve › L-type voltage-gated calcium channel agonists...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Mécanotransduction cellulaire › L-type voltage-gated calcium channel agonists...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › L-type voltage-gated calcium channel agonists...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Myosines › L-type voltage-gated calcium channel agonists...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Réflexe › Réflexe de sursaut › L-type voltage-gated calcium channel agonists...
questionsmedicales.fr › Cellules › Structures cellulaires › Prolongements cytoplasmiques › Stéréocils › L-type voltage-gated calcium channel agonists...
questionsmedicales.fr › Activités humaines › Activités de loisirs › Loisir › Sports › Sports nautiques › Natation › L-type voltage-gated calcium channel agonists...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › L-type voltage-gated calcium channel agonists...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Troubles sensitifs › Troubles de l'audition › Perte d'audition › Surdité neurosensorielle › Syndromes d'Usher › L-type voltage-gated calcium channel agonists...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › L-type voltage-gated calcium channel agonists...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de poisson › Protéines de poisson-zèbre › L-type voltage-gated calcium channel agonists...