Characterization of T-cell receptor transgenic mice recognizing immunodominant HLA-DQ2.5-restricted gluten epitopes.

Animals CD4-Positive T-Lymphocytes / immunology Celiac Disease / genetics Disease Models, Animal Glutens / genetics HLA-DQ Antigens / genetics Humans Immunodominant Epitopes / genetics Mice Mice, Transgenic Receptors, Antigen, T-Cell / genetics
HLA-DQ2.5 TCR celiac gluten mouse

Journal

European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201

Informations de publication

Date de publication:
04 2021
Historique:
revised: 02 10 2020
received: 01 07 2020
accepted: 27 11 2020
pubmed: 29 12 2020
medline: 21 9 2021
entrez: 28 12 2020
Statut: ppublish

Résumé

We created a TCR transgenic mouse with CD4

Identifiants

DOI: 10.1002/eji.202048859 PMID: 33368209
pubmed: 33368209
doi: 10.1002/eji.202048859
doi:

Substances chimiques

HLA-DQ Antigens 0
HLA-DQ2 antigen 0
Immunodominant Epitopes 0
Receptors, Antigen, T-Cell 0
Glutens 8002-80-0

Types de publication

Letter Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1002-1005

Informations de copyright

© 2020 Wiley-VCH GmbH.

Références

Lindfors, K. et al., Nat. Rev. Dis. Primers 2019. 5: 3.
Tye-Din, J. A. et al., Sci. Transl. Med. 2010. 2: 41ra51.
du Pré, M. F. et al., J. Exp. Med. 2020. 217.
Du Pré, M. F. et al., Gastroenterology 2011. 141: 610-620, 620 e611-612.
Siegel, M. et al., PLoS One 2008. 3: e1861.
Dorum, S. et al., J. Proteome Res. 2009. 8: 1748-1755.

Auteurs

Christian B Lindstad (CB)

K.G. Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway.
Department of Immunology, University of Oslo, Oslo, Norway.
ORCID: 0000-0003-4450-6970

Shuo-Wang Qiao (SW)

K.G. Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway.
Department of Immunology, University of Oslo, Oslo, Norway.

Marie K Johannesen (MK)

K.G. Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway.
Department of Immunology, University of Oslo, Oslo, Norway.

Lars Fugger (L)

Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology and Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.

Ludvig M Sollid (LM)

K.G. Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway.
Department of Immunology, University of Oslo, Oslo, Norway.
Department of Immunology, Oslo University Hospital, Oslo, Norway.

M Fleur du Pré (MF)

K.G. Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway.
Department of Immunology, Oslo University Hospital, Oslo, Norway.
ORCID: 0000-0001-9231-643X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Characterization of T-cell receptor transgenic...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Characterization of T-cell receptor transgenic...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Syndromes de malabsorption › Maladie coeliaque › Characterization of T-cell receptor transgenic...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Characterization of T-cell receptor transgenic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines végétales › Protéines de stockage des graines › Prolamines › Glutens › Characterization of T-cell receptor transgenic...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes HLA › Antigènes HLA-D › Antigènes HLA-DQ › Characterization of T-cell receptor transgenic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Characterization of T-cell receptor transgenic...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Épitopes immunodominants › Characterization of T-cell receptor transgenic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Characterization of T-cell receptor transgenic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Characterization of T-cell receptor transgenic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › Characterization of T-cell receptor transgenic...