Cortico-striato-thalamo-cerebellar networks of structural covariance underlying different epilepsy syndromes associated with generalized tonic-clonic seizures.
Adult
Cerebellum
/ diagnostic imaging
Cerebral Cortex
/ diagnostic imaging
Connectome
Corpus Striatum
/ diagnostic imaging
Epilepsy, Tonic-Clonic
/ diagnostic imaging
Epileptic Syndromes
/ diagnostic imaging
Female
Gray Matter
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
Male
Nerve Net
/ diagnostic imaging
Thalamus
/ diagnostic imaging
Young Adult
cortico-striato-thalamo-cerebellar network
epilepsy
generalized tonic-clonic seizures
morhpometric MRI
structural covariance connecvity
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
05
05
2020
revised:
16
09
2020
accepted:
31
10
2020
pubmed:
30
12
2020
medline:
4
1
2022
entrez:
29
12
2020
Statut:
ppublish
Résumé
Generalized tonic-clonic seizures (GTCS) are the severest and most remarkable clinical expressions of human epilepsy. Cortical, subcortical, and cerebellar structures, organized with different network patterns, underlying the pathophysiological substrates of genetic associated epilepsy with GTCS (GE-GTCS) and focal epilepsy associated with focal to bilateral tonic-clonic seizure (FE-FBTS). Structural covariance analysis can delineate the features of epilepsy network related with long-term effects from seizure. Morphometric MRI data of 111 patients with GE-GTCS, 111 patients with FE-FBTS and 111 healthy controls were studied. Cortico-striato-thalao-cerebellar networks of structural covariance within the gray matter were constructed using a Winner-take-all strategy with five cortical parcellations. Comparisons of structural covariance networks were conducted using permutation tests, and module effects of disease duration on networks were conducted using GLM model. Both patient groups showed increased connectivity of structural covariance relative to controls, mainly within the striatum and thalamus, and mostly correlated with the frontal, motor, and somatosensory cortices. Connectivity changes increased as a function of epilepsy durations. FE-FBTS showed more intensive and extensive gray matter changes with volumetric loss and connectivity increment than GE-GTCS. Our findings implicated cortico-striato-thalamo-cerebellar network changes at a large temporal scale in GTCS, with FE-FBTS showing more severe network disruption. The study contributed novel imaging evidence for understanding the different epilepsy syndromes associated with generalized seizures.
Identifiants
pubmed: 33372704
doi: 10.1002/hbm.25279
pmc: PMC7856655
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1102-1115Informations de copyright
© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
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