Adult
Aged
Biomarkers, Tumor
/ genetics
Cohort Studies
CpG Islands
/ genetics
DNA Methylation
Epigenesis, Genetic
Exons
/ genetics
Gene Expression Regulation, Neoplastic
Humans
Male
Middle Aged
Neoplasm Grading
Prostate
/ pathology
Prostatectomy
Prostatic Neoplasms
/ diagnosis
Proto-Oncogene Proteins c-myc
/ genetics
RNA, Long Noncoding
/ genetics
DNA methylation
Gleason score (GS)
MYC
RNA expression
aggressive disease
non-coding RNAs (ncRNAs)
prostate cancer
tumor tissue biomarkers
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
24 12 2020
24 12 2020
Historique:
received:
28
09
2020
revised:
20
11
2020
accepted:
11
12
2020
entrez:
30
12
2020
pubmed:
31
12
2020
medline:
30
7
2021
Statut:
epublish
Résumé
Increasing evidence suggests a role of epigenetic mechanisms at chromosome 8q24, an important cancer genetic susceptibility region, in prostate cancer. We investigated whether
Identifiants
pubmed: 33374332
pii: genes12010012
doi: 10.3390/genes12010012
pmc: PMC7823928
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
MYC protein, human
0
PRNCR1 long non-coding RNA, human
0
Proto-Oncogene Proteins c-myc
0
RNA, Long Noncoding
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : BLRD VA
ID : I01 BX000545
Pays : United States
Organisme : NCI NIH HHS
ID : K07 CA230182
Pays : United States
Organisme : NCI NIH HHS
ID : P30CA134274
Pays : United States
Déclaration de conflit d'intérêts
L.Y., M.P. and A.M. are employed by EpigenDx, Inc, and L.Y. is the major stockholder of EpigenDx. All other authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
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