Peripheral Blood Immune Profiling of Convalescent Plasma Donors Reveals Alterations in Specific Immune Subpopulations Even at 2 Months Post SARS-CoV-2 Infection.
Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Viral
/ blood
B-Lymphocytes
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
COVID-19
/ immunology
Female
Humans
Immunity, Humoral
Immunization, Passive
Male
Middle Aged
Plasma
/ immunology
SARS-CoV-2
/ immunology
Th1 Cells
Th17 Cells
Th2 Cells
Time Factors
Young Adult
COVID-19 Serotherapy
COVID-19
SARS-CoV-2
convalescent plasma donors
immune profiling
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
25 12 2020
25 12 2020
Historique:
received:
22
11
2020
revised:
19
12
2020
accepted:
22
12
2020
entrez:
30
12
2020
pubmed:
31
12
2020
medline:
20
1
2021
Statut:
epublish
Résumé
Immune profiling of patients with COVID-19 has shown that SARS-CoV-2 causes severe lymphocyte deficiencies (e.g., lymphopenia, decreased numbers, and exhaustion of T cells) and increased levels of pro-inflammatory monocytes. Peripheral blood (PB) samples from convalescent plasma (CP) donors, COVID-19 patients, and control subjects were analyzed by multiparametric flow cytometry, allowing the identification of a wide panel of immune cells, comprising lymphocytes (T, B, natural killer (NK) and NKT cells), monocytes, granulocytes, and their subsets. Compared to active COVID-19 patients, our results revealed that the immune profile of recovered donors was restored for most subpopulations. Nevertheless, even 2 months after recovery, CP donors still had reduced levels of CD4
Identifiants
pubmed: 33375675
pii: v13010026
doi: 10.3390/v13010026
pmc: PMC7824046
pii:
doi:
Substances chimiques
Antibodies, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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