Altered Cl


Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
12 01 2021
Historique:
entrez: 30 12 2020
pubmed: 31 12 2020
medline: 19 5 2021
Statut: ppublish

Résumé

Impairments of inhibitory circuits are at the basis of most, if not all, cognitive deficits. The impact of OPHN1, a gene associate with intellectual disability (ID), on inhibitory neurons remains elusive. We addressed this issue by analyzing the postnatal migration of inhibitory interneurons derived from the subventricular zone in a validated mouse model of ID (OPHN1

Identifiants

pubmed: 33376209
pii: 2016034118
doi: 10.1073/pnas.2016034118
pmc: PMC7812749
pii:
doi:

Substances chimiques

Chlorides 0
Cytoskeletal Proteins 0
GTPase-Activating Proteins 0
Nuclear Proteins 0
Ophn1 protein, mouse 0
RhoA protein, mouse EC 3.6.5.2
rhoA GTP-Binding Protein EC 3.6.5.2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Déclaration de conflit d'intérêts

The authors declare no competing interest.

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Auteurs

Andrea Maset (A)

Veneto Institute of Molecular Medicine, 35129 Padua, Italy.
Padova Neuroscience Center, 35129 Padova, Italy.
Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy.

Luisa Galla (L)

Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy.
Neuroscience Institute, National Research Council, 35127 Padua, Italy.

Simona Francia (S)

Veneto Institute of Molecular Medicine, 35129 Padua, Italy.
Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, 16132 Genoa, Italy.

Olga Cozzolino (O)

Istituto Nanoscienze, Consiglio Nazionale delle Ricerche, 56127 Pisa, Italy.
National Enterprise for nanoScience and nanoTechnology, Scuola Normale Superiore, 56127 Pisa, Italy.

Paola Capasso (P)

San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Rosa Chiara Goisis (RC)

Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy.
Neuroscience Institute, National Research Council, 35127 Padua, Italy.

Gabriele Losi (G)

Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy.
Neuroscience Institute, National Research Council, 35127 Padua, Italy.

Angelo Lombardo (A)

San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Vita-Salute San Raffaele University, 20132 Milan, Italy.

Gian Michele Ratto (GM)

Istituto Nanoscienze, Consiglio Nazionale delle Ricerche, 56127 Pisa, Italy.
National Enterprise for nanoScience and nanoTechnology, Scuola Normale Superiore, 56127 Pisa, Italy.

Claudia Lodovichi (C)

Veneto Institute of Molecular Medicine, 35129 Padua, Italy; claudia.lodovichi@unipd.it.
Padova Neuroscience Center, 35129 Padova, Italy.
Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy.
Neuroscience Institute, National Research Council, 35127 Padua, Italy.

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Classifications MeSH