Multi-scale architecture of archaeal chromosomes.
chromosome conformation, archaea, Sulfolobus, SMC, coalescin, TAD, CID
Journal
Molecular cell
ISSN: 1097-4164
Titre abrégé: Mol Cell
Pays: United States
ID NLM: 9802571
Informations de publication
Date de publication:
04 02 2021
04 02 2021
Historique:
received:
19
05
2020
revised:
15
10
2020
accepted:
30
11
2020
pubmed:
1
1
2021
medline:
25
2
2021
entrez:
31
12
2020
Statut:
ppublish
Résumé
Chromosome conformation capture (3C) technologies have identified topologically associating domains (TADs) and larger A/B compartments as two salient structural features of eukaryotic chromosomes. These structures are sculpted by the combined actions of transcription and structural maintenance of chromosomes (SMC) superfamily proteins. Bacterial chromosomes fold into TAD-like chromosomal interaction domains (CIDs) but do not display A/B compartment-type organization. We reveal that chromosomes of Sulfolobus archaea are organized into CID-like topological domains in addition to previously described larger A/B compartment-type structures. We uncover local rules governing the identity of the topological domains and their boundaries. We also identify long-range loop structures and provide evidence of a hub-like structure that colocalizes genes involved in ribosome biogenesis. In addition to providing high-resolution descriptions of archaeal chromosome architectures, our data provide evidence of multiple modes of organization in prokaryotic chromosomes and yield insights into the evolution of eukaryotic chromosome conformation.
Identifiants
pubmed: 33382983
pii: S1097-2765(20)30893-5
doi: 10.1016/j.molcel.2020.12.001
pmc: PMC7867652
mid: NIHMS1654324
pii:
doi:
Substances chimiques
Chromatin
0
DNA, Archaeal
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
473-487.e6Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM135178
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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