The regulation of Saccharomyces cerevisiae Snf1 protein kinase on glucose utilization is in a glucose-dependent manner.
Glucose metabolism
Saccharomyces cerevisiae
Snf1 protein kinase
Stress response
Journal
Current genetics
ISSN: 1432-0983
Titre abrégé: Curr Genet
Pays: United States
ID NLM: 8004904
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
06
08
2020
accepted:
21
11
2020
revised:
19
11
2020
pubmed:
2
1
2021
medline:
4
8
2021
entrez:
1
1
2021
Statut:
ppublish
Résumé
Protein phosphorylation catalyzed by protein kinases is the major regulatory mechanism that controls many cellular processes. The regulatory mechanism of one protein kinase in different signals is distinguished, probably inducing multiple phenotypes. The Saccharomyces cerevisiae Snf1 protein kinase, a member of the AMP‑activated protein kinase family, plays important roles in the response to nutrition and environmental stresses. Glucose is an important nutrient for life activities of cells, but glucose repression and osmotic pressure could be produced at certain concentrations. To deeply understand the role of Snf1 in the regulation of nutrient metabolism and stress response of S. cerevisiae cells, the role and the regulatory mechanism of Snf1 in glucose metabolism are discussed in different level of glucose: below 1% (glucose derepression status), in 2% (glucose repression status), and in 30% glucose (1.66 M, an osmotic equivalent to 0.83 M NaCl). In summary, Snf1 regulates glucose metabolism in a glucose-dependent manner, which is associated with the different regulation on activation, localization, and signal pathways of Snf1 by varied glucose. Exploring the regulatory mechanism of Snf1 in glucose metabolism in different concentrations of glucose can provide insights into the study of the global regulatory mechanism of Snf1 in yeast and can help to better understand the complexity of physiological response of cells to stresses.
Identifiants
pubmed: 33385241
doi: 10.1007/s00294-020-01137-0
pii: 10.1007/s00294-020-01137-0
doi:
Substances chimiques
Protein Kinases
EC 2.7.-
SNF1-related protein kinases
EC 2.7.1.-
Protein Serine-Threonine Kinases
EC 2.7.11.1
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
245-248Subventions
Organisme : the Scientific Research Foundation of Hainan University
ID : KYQD1660
Références
Backhaus K, Rippert D, Heilmann CJ, Sorgo AG, de Koster CG, Klis FM, Rodicio R, Heinisch JJ (2013) Mutations in SNF1 complex genes affect yeast cell wall strength. Eur J Cell Biol 92:383–395. https://doi.org/10.1016/j.ejcb.2014.01.001
doi: 10.1016/j.ejcb.2014.01.001
pubmed: 24486034
Barrett L, Orlova M, Maziarz M, Kuchin S (2012) Protein kinase A contributes to the negative control of Snf1 protein kinase in Saccharomyces cerevisiae. Eukaryot Cell 11:119–128. https://doi.org/10.1128/EC.05061-11
doi: 10.1128/EC.05061-11
pubmed: 22140226
pmcid: 3272905
Casamayor A, Serrano R, Platara M, Casado C, Ruiz A, Ariño J (2012) The role of the Snf1 kinase in the adaptive response of Saccharomyces cerevisiae to alkaline pH stress. Biochem J 444:39–49. https://doi.org/10.1042/BJ20112099
doi: 10.1042/BJ20112099
pubmed: 22372618
Coccetti P, Nicastro R, Tripodi F (2018) Conventional and emerging roles of the energy sensor Snf1/AMPK in Saccharomyces cerevisiae. Microbial Cell 5:482–494. https://doi.org/10.15698/mic2018.11.655
doi: 10.15698/mic2018.11.655
pubmed: 30483520
pmcid: 6244292
Daniel T, Carling D (2002) Expression and regulation of the AMP-activated protein kinase-SNF1 (sucrose non-fermenting 1) kinase complexes in yeast and mammalian cells: studies using chimaeric catalytic subunits. Biochem J 365:629–638. https://doi.org/10.1042/BJ20020124
doi: 10.1042/BJ20020124
pubmed: 11971761
pmcid: 1222717
Gowans GJ, Hardie DG (2014) AMPK: a cellular energy sensor primarily regulated by AMP. Biochem Soc Trans 42:71–75. https://doi.org/10.1042/BST20130244
doi: 10.1042/BST20130244
pubmed: 24450630
pmcid: 5703408
Gowans GJ, Hawley SA, Ross FA, Hardie DG (2013) AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation. Cell Metab 18:556–566. https://doi.org/10.1016/j.cmet.2013.08.019
doi: 10.1016/j.cmet.2013.08.019
pubmed: 24093679
pmcid: 3791399
Hedbacker K, Carlson M (2008) SNF1/AMPK pathways in yeast. Front Biosci 13:2408–2420. https://doi.org/10.2741/2854
doi: 10.2741/2854
pubmed: 17981722
pmcid: 2685184
Hedbacker K, Hong SP, Carlson M (2004) Pak1 protein kinase regulates activation and nuclear localization of Snf1-Gal83 protein kinase. Mol Cell Biol 24:8255–8263. https://doi.org/10.1128/MCB.24.18.8255-8263.2004
doi: 10.1128/MCB.24.18.8255-8263.2004
pubmed: 15340085
pmcid: 515071
Hong SP, Carlson M (2007) Regulation of snf1 protein kinase in response to environmental stress. J Biol Chem 282:16838–16845. https://doi.org/10.1074/jbc.M700146200
doi: 10.1074/jbc.M700146200
pubmed: 17438333
Hong SP, Leiper FC, Woods A, Carling D, Carlson M (2003) Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases. Proc Natl Acad Sci USA 100:8839–8843. https://doi.org/10.1073/pnas.1533136100
doi: 10.1073/pnas.1533136100
pubmed: 12847291
Liu Y, Xu X, Carlson M (2011) Interaction of SNF1 protein kinase with its activating kinase Sak1. Eukaryot Cell 10:313–319. https://doi.org/10.1128/EC.00291-10
doi: 10.1128/EC.00291-10
pubmed: 21216941
pmcid: 3067465
Ludin K, Jiang R, Carlson M (1998) Glucose-regulated interaction of a regulatory subunit of protein phosphatase 1 with the Snf1 protein kinase in Saccharomyces cerevisiae. P Natl Acad Sci USA 95:6245–6250. https://doi.org/10.1073/pnas.95.11.6245
doi: 10.1073/pnas.95.11.6245
Martinez-Ortiz C, Carrillo-Garmendia A, Correa-Romero BF, Canizal-García M, González-Hernández JC, Regalado-Gonzalez C, Olivares-Marin IK, Madrigal-Perez LA (2019) SNF1 controls the glycolytic flux and mitochondrial respiration. Yeast 36:1–8. https://doi.org/10.1002/yea.3399
doi: 10.1002/yea.3399
Meng L, Liu HL, Lin X, Hu XP, Teng KR, Liu SX (2020) Enhanced multi-stress tolerance and glucose utilization of Saccharomyces cerevisiae by overexpression of the SNF1 gene and varied beta isoform of Snf1 dominates in stresses. Microb Cell Fact 19:134. https://doi.org/10.1186/s12934-020-01391-4
doi: 10.1186/s12934-020-01391-4
pubmed: 32571355
pmcid: 7310068
Momcilovic M, Iram SH, Liu Y, Carlson M (2008) Roles of the glycogen-binding domain and Snf4 in glucose inhibition of SNF1 protein kinase. J Biol Chem 283:19521–19529. https://doi.org/10.1074/jbc.M803624200
doi: 10.1074/jbc.M803624200
pubmed: 18474591
pmcid: 2443652
Nicastro R, Tripodi F, Guzzi C, Reghellin V, Khoomrung S, Capusoni C, Compagno C, Airoldi C, Nielsen J, Alberghina L, Coccetti P (2015) Enhanced amino acid utilization sustains growth of cells lacking Snf1/AMPK. Biochim Biophys Acta 1853:1615–1625. https://doi.org/10.1016/j.bbamcr.2015.03.014
doi: 10.1016/j.bbamcr.2015.03.014
pubmed: 25841981
Östling J, Ronne H (1998) Negative control of the Mig1p repressor by Snf1p-dependant phosphorylation in the absence of glucose. Eur J Biochem 252:162–168. https://doi.org/10.1046/j.1432-1327.1998.2520162.x
doi: 10.1046/j.1432-1327.1998.2520162.x
pubmed: 9523726
Papamichos-Chronakis M, Gligoris T, Tzamarias D (2004) The Snf1 kinase controls glucose repression in yeast by modulating interactions between the Mig1 repressor and the Cyc8-Tup1 co-repressor. EMBO Rep 5:368–372. https://doi.org/10.1038/sj.embor.7400120
doi: 10.1038/sj.embor.7400120
pubmed: 15031717
pmcid: 1299031
Pasula S, Jouandot D, Kim JH (2007) Biochemical evidence for glucose-independent induction of HXT expression in Saccharomyces cerevisiae. FEBS Lett 581:3230–3234. https://doi.org/10.1016/j.febslet.2007.06.013
doi: 10.1016/j.febslet.2007.06.013
pubmed: 17586499
pmcid: 2040036
Raúl G-S, Lubitz T, Beltran G, Elbing K, Tian Y, Frey S, Wolkenhauer O, Krantz M, Klipp E, Hohmann S (2014) Glucose de-repression by yeast AMP-activated proteinkinase SNF1 is controlled via at least two independentsteps. FEBS J 281:1901–1917. https://doi.org/10.1111/febs.12753
doi: 10.1111/febs.12753
Rubenstein EM, McCartney RR, Zhang C, Shokat KM, Shirra MK, Arndt KM, Schmidt MC (2008) Access denied: Snf1 activation loop phosphorylation is controlled by availability of the phosphorylated threonine 210 to the PP1 phosphatase. J Biol Chem 283:222–230. https://doi.org/10.1074/jbc.M707957200
doi: 10.1074/jbc.M707957200
pubmed: 17991748
Shashkova S, Welkenhuysen N, Hohmann S (2015) Molecular communication: crosstalk between the Snf1 and other signaling pathways. FEMS Yeast Res 15:fov026. https://doi.org/ https://doi.org/10.1093/femsyr/fov026
Simpson-Lavy KJ, Johnston M (2013) SUMOylation regulates the SNF1 protein kinase. Proc Natl Acad Sci U S A 110:17432–17437. https://doi.org/10.1073/pnas.1304839110
doi: 10.1073/pnas.1304839110
pubmed: 24108357
pmcid: 3808588
Souid AK, Gao C, Wang L, Milgrom E, Shen WWC (2006) ELM1 is required for multidrug resistance in Saccharomyces cerevisiae. Genetics 173:1919–1937. https://doi.org/10.1534/genetics.106.057596
doi: 10.1534/genetics.106.057596
pubmed: 16751665
pmcid: 1569693
Vincent O, Townley R, Kuchin S, Carlson M (2001) Subcellular localization of the Snf1 kinase is regulated by specific beta subunits and a novel glucose signaling mechanism. Genes Dev 15:1104–1114. https://doi.org/10.1101/gad.879301
doi: 10.1101/gad.879301
pubmed: 11331606
pmcid: 312685
Wang D, Li Y, Wang H, Wei D, Akhberdi O, Liu Y, Xiang B, Hao X, Zhu X (2018) The AMP-activated protein kinase homolog Snf1 concerts carbon utilization, conidia production and the biosynthesis of secondary metabolites in the taxol-producer Pestalotiopsis microspora. Genes 9:59. https://doi.org/10.3390/genes9020059
doi: 10.3390/genes9020059
pmcid: 5852555
Wilson WA, Hawley SA, Hardie DG (1996) Glucose repression/derepression in budding yeast: SNF1 protein kinase is activated by phosphorylation under derepressing conditions, and this correlates with a high AMP:ATP ratio. Curr Biol 6:1426–1434. https://doi.org/10.1016/S0960-9822(96)00747-6
doi: 10.1016/S0960-9822(96)00747-6
pubmed: 8939604
Zhang J, Vaga S, Chumnanpuen P, Kumar R, Vemuri GN, Aebersold R, Nielsen J (2011) Mapping the interaction of Snf1 with TORC1 in Saccharomyces cerevisiae. Mol Syst Biol 7:545. https://doi.org/10.1038/msb.2011.80
doi: 10.1038/msb.2011.80
pubmed: 22068328
pmcid: 3261716
Zhang CY, Bai XW, Lin X, Liu XE, Xiao DG (2015) Effects of SNF1 on maltose metabolism and leavening ability of baker’s yeast in lean dough. J Food Sci 80:M2879-2885. https://doi.org/10.1111/1750-3841.13137
doi: 10.1111/1750-3841.13137
pubmed: 26580148