Design, synthesis and SAR of antitubercular benzylpiperazine ureas.
Antitubercular
Benzylpiperazine ureas
Lead compounds
QcrB inhibitors
Journal
Molecular diversity
ISSN: 1573-501X
Titre abrégé: Mol Divers
Pays: Netherlands
ID NLM: 9516534
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
10
09
2020
accepted:
17
11
2020
pubmed:
2
1
2021
medline:
3
3
2022
entrez:
1
1
2021
Statut:
ppublish
Résumé
N-furfuryl piperazine ureas disclosed by scientists at GSK Tres Cantos were chosen as antimycobacterial hits from a phenotypic whole-cell screen. Bioisosteric replacement of the furan ring in the GSK Tres Cantos molecules with a phenyl ring led to molecule (I) with an MIC of 1 μM against Mtb H37Rv, low cellular toxicity (HepG2 IC
Identifiants
pubmed: 33385288
doi: 10.1007/s11030-020-10158-3
pii: 10.1007/s11030-020-10158-3
doi:
Substances chimiques
Antitubercular Agents
0
Piperazines
0
Urea
8W8T17847W
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
73-96Informations de copyright
© 2021. Springer Nature Switzerland AG.
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