Cytogenetic and molecular aberrations and worse outcome for male patients in systemic mastocytosis.


Journal

Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395

Informations de publication

Date de publication:
2021
Historique:
received: 12 08 2020
accepted: 23 09 2020
entrez: 4 1 2021
pubmed: 5 1 2021
medline: 6 8 2021
Statut: epublish

Résumé

In systemic mastocytosis (SM), the clinical features and survival vary greatly. Patient-related factors determining the outcome in SM are largely unknown.

Identifiants

pubmed: 33391475
doi: 10.7150/thno.51872
pii: thnov11p0292
pmc: PMC7681091
doi:

Substances chimiques

ASXL1 protein, human 0
Core Binding Factor Alpha 2 Subunit 0
RUNX1 protein, human 0
Repressor Proteins 0
SRSF2 protein, human 147153-65-9
Serine-Arginine Splicing Factors 170974-22-8
KIT protein, human EC 2.7.10.1
Proto-Oncogene Proteins c-kit EC 2.7.10.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

292-303

Informations de copyright

© The author(s).

Déclaration de conflit d'intérêts

Competing Interests: Hanneke C. Kluin-Nelemans: institutional financial support from Novartis; honoraria from Novartis for participating in e-learning program. Andreas Reiter: Novartis Pharma - research support, advisory board, honoraria, travel reimbursement, Blueprint Medicines - advisory board, honoraria, travel reimbursement, Deciphera - advisory board, travel reimbursement. Bjorn van Anrooij: financial support from Novartis for research and advisory boards. Jason Gotlib: Funding to support conduct of clinical trial: Blueprint Medicines, Deciphera; advisory board/honoraria: Blueprint Medicines, Deciphera, Allakos. Karin Hartmann: advisory board/honoraria: Allergopharma, ALK-Abelló, Blueprint, Deciphera, Menarini, Novartis and Takeda; research grant: Euroimmun. Hanneke Oude Elberink: honoraria from ALK-Abelló, Chiesi, MEDA Pharma, Novartis, and Blueprint. Magdalena Lange: honoraria from Novartis for lectures. Chiara Elena: advisory board Novartis, Pfizer. David Fuchs, Julien Rossignol: advisory board Novartis. Khalid Shoumariyeh: travel support from Abbvie and consultancy fees from Novartis. Nikolas von Bubnoff: institutional financial support from Novartis. Massimo Triggiani: advisory board BluePrint Medicines, Deciphera, Novartis. Akif SelimYavuz: honoraria from Novartis. Jens Panse: funding to support conduct of clinical trial: Blueprint Medicines, Deciphera; advisory board/honoraria: Blueprint Medicines, Novartis. Vito Sabato: advisory board/honoraria: Blueprint Medicines, Novartis. Madlen Jentzsch: honoraria from Novartis. Olivier Hermine: Research funding support from AB science and Novartis. Advisory board of AB science. Wolfgang R. Sperr: honoraria from Novartis, Pfizer, AbbVie, Daiichi Sankyo, Amgen, Thermo Fisher, Deciphera, Incyte, Celgene and Jazz. Michel Arock: advisory board/honoraria Blueprint Medicines, Deciphera. All other authors: none.

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Auteurs

Hanneke C Kluin-Nelemans (HC)

Department of Haematology University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Mohamad Jawhar (M)

III. Medizinische Klinik, Universitätsmedizin Mannheim, Universität Heidelberg, Mannheim, Germany.

Andreas Reiter (A)

III. Medizinische Klinik, Universitätsmedizin Mannheim, Universität Heidelberg, Mannheim, Germany.

Bjorn van Anrooij (B)

Department of Haematology University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Internal Medicine, section Allergology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Jason Gotlib (J)

Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, USA.

Karin Hartmann (K)

Division of Allergy, Department of Dermatology, University of Basel, Basel, Switzerland (KH); Department of Biomedicine, University of Basel, Basel, Switzerland.

Anja Illerhaus (A)

Department of Dermatology and Venerology, Uniklinik Köln, Köln, Germany.

Hanneke N G Oude Elberink (HNG)

Internal Medicine, section Allergology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Aleksandra Gorska (A)

Department of Allergology, Medical University of Gdansk, Gdańsk, Poland.

Marek Niedoszytko (M)

Department of Allergology, Medical University of Gdansk, Gdańsk, Poland.

Magdalena Lange (M)

Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdańsk, Poland.

Luigi Scaffidi (L)

Section of Hematology, Department of Medicine, Verona University Hospital, Verona, Italy.

Roberta Zanotti (R)

Section of Hematology, Department of Medicine, Verona University Hospital, Verona, Italy.

Patrizia Bonadonna (P)

Allergy Unit, Verona University Hospital, Verona, Italy.

Cecelia Perkins (C)

Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, USA.

Chiara Elena (C)

Department of Molecular Medicine and Department of Hematology Oncology, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Luca Malcovati (L)

Department of Molecular Medicine and Department of Hematology Oncology, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Khalid Shoumariyeh (K)

Department of Hematology, Oncology and Stem Cell Transplantation, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK) Partner Site Freiburg, Freiburg, Germany.

Nikolas von Bubnoff (N)

Department of Hematology, Oncology and Stem Cell Transplantation, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK) Partner Site Freiburg, Freiburg, Germany.
Department of Hematology and Oncology, Medical Center, University of Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.

Sabine Müller (S)

Department of Dermatology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; German Cancer Consortium (DKTK) Partner Site Freiburg, Freiburg, Germany.

Massimo Triggiani (M)

Division of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy.

Roberta Parente (R)

Division of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy.

Juliana Schwaab (J)

III. Medizinische Klinik, Universitätsmedizin Mannheim, Universität Heidelberg, Mannheim, Germany.

Michael Kundi (M)

Institute of Environmental Health, Medical University of Vienna, Vienna, Austria.

Anna Belloni Fortina (AB)

Pediatric Dermatology Unit, Department of Medicine, University of Padova, Padova, Italy.

Francesca Caroppo (F)

Pediatric Dermatology Unit, Department of Medicine, University of Padova, Padova, Italy.

Knut Brockow (K)

Department of Dermatology and Allergy Biederstein, School of Medicine, Technical University of Munich, Munich, Germany.

Alexander Zink (A)

Department of Dermatology and Allergy Biederstein, School of Medicine, Technical University of Munich, Munich, Germany.

David Fuchs (D)

University Clinic for Hematology and Oncology, Kepler University Hospital, Johannes Kepler University, Linz, Austria.

Irena Angelova-Fischer (I)

Department of Dermatology and Venereology, Allergy Centrr, Kepler University Hospital, Linz, Austria.

Akif Selim Yavuz (AS)

Division of Hematology, Istanbul Medical School, University of Istanbul, Istanbul, Turkey.

Michael Doubek (M)

University Hospital and CEITEC Masaryk University, Brno, Czech Republic.

Mattias Mattsson (M)

Dept Immunol, Genetics and Pathology (MM) and Dept Hematol (MM, HH), Uppsala University Hospital, Uppsala University, Uppsala, Sweden.

Hans Hagglund (H)

Dept Immunol, Genetics and Pathology (MM) and Dept Hematol (MM, HH), Uppsala University Hospital, Uppsala University, Uppsala, Sweden.

Jens Panse (J)

Department of Oncology, Hematology, Hemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany.

Anne Simonowski (A)

Department of Oncology, Hematology, Hemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany.

Vito Sabato (V)

Faculty of Medicine and Health Sciences, Department of Immunology-Allergology-Rheumatology, University of Antwerp and Antwerp University Hospital, Antwerpen, Belgium.

Tanja Schug (T)

Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.

Madlen Jentzsch (M)

Medical Clinic and Policlinic 1, Hematology and Cellular Therapy,Leipzig University Hospital,Germany.

Christine Breynaert (C)

Department of Dermatology, University Hospitals Leuven, Leuven, Belgium.

Judit Várkonyi (J)

Department of Hematology, Semmelweis University, Budapest, Hungary.

Vanessa Kennedy (V)

Division of Hematology/Oncology, Department of Medicine, University of California San Francisco, San Francisco, USA.

Olivier Hermine (O)

French Reference Center for Mastocytosis (CEREMAST), Hôpital Necker, Assistance Publique Hôpitauxde Paris, Imagine Institute, University Paris Descartes, Paris, France.

Julien Rossignol (J)

Department of Hematology, Gustave Roussy Cancer Center, Villejuif, France.

Michel Arock (M)

Laboratory of Hematology, Pitié-Salpêtrière Hospital, Paris, France.

Peter Valent (P)

Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
Ludwig Boltzmann Institute for Hematology and Oncology.

Wolfgang R Sperr (WR)

Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
Ludwig Boltzmann Institute for Hematology and Oncology.

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