Engineering ribose-5-phosphate isomerase B from a central carbon metabolic enzyme to a promising sugar biocatalyst.
Biocatalysis
Central carbon metabolism
Enzyme engineering
Rare sugar
Ribose-5-phosphate isomerase B
Substrate scope
Journal
Applied microbiology and biotechnology
ISSN: 1432-0614
Titre abrégé: Appl Microbiol Biotechnol
Pays: Germany
ID NLM: 8406612
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
07
10
2020
accepted:
23
12
2020
revised:
12
12
2020
pubmed:
5
1
2021
medline:
15
5
2021
entrez:
4
1
2021
Statut:
ppublish
Résumé
Ribose-5-phosphate isomerase B (RpiB) was first identified in the pentose phosphate pathway responsible for the inter-conversion of ribose-5-phosphate and ribulose-5-phosphate. Though there are seldom key enzymes in central carbon metabolic system developed as useful biocatalysts, RpiB with the advantages of wide substrate scope and high stereoselectivity has become a potential biotechnological tool to fulfill the demand of rare sugars currently. In this review, the pivotal roles of RpiB in carbon metabolism are summarized, and their sequence identity and structural similarity are discussed. Substrate binding and catalytic mechanisms are illustrated to provide solid foundations for enzyme engineering. Interesting differences in origin, physiological function, structure, and catalytic mechanism between RpiB and ribose-5-phosphate isomerase A are introduced. Moreover, enzyme engineering efforts for rare sugar production are stressed, and prospects of future development are concluded briefly in the viewpoint of biocatalysis. Aided by the progresses of structural and computational biology, the application of RpiB will be promoted greatly in the preparation of valuable molecules. KEY POINTS: • Detailed illustration of RpiB's vital function in central carbon metabolism. • Potential of RpiB in sequence, substrate scope, and mechanism for application. • Enzyme engineering efforts to promote RpiB in the preparation of rare sugars.
Identifiants
pubmed: 33394147
doi: 10.1007/s00253-020-11075-z
pii: 10.1007/s00253-020-11075-z
doi:
Substances chimiques
Sugars
0
Carbon
7440-44-0
Aldose-Ketose Isomerases
EC 5.3.1.-
ribosephosphate isomerase
EC 5.3.1.6
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
509-523Subventions
Organisme : National Natural Science Foundation of China
ID : No. 21676173
Organisme : National Natural Science Foundation of China
ID : No.21376156
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