Steroid Receptor Coactivator-3 Is Required for Inhibition of the Intestinal Muscularis Inflammatory Response of Postoperative Ileus in Mice.
Animals
Cytokines
/ metabolism
Disease Models, Animal
Female
Gastrointestinal Motility
Ileus
/ etiology
Inflammation Mediators
/ metabolism
Intestine, Small
/ immunology
Jejunum
/ immunology
Mice, 129 Strain
Mice, Inbred C57BL
Mice, Knockout
Muscle, Smooth
/ immunology
Neutrophil Infiltration
Nuclear Receptor Coactivator 3
/ genetics
Peroxidase
/ metabolism
Postoperative Complications
/ etiology
Tissue Culture Techniques
inflammatory mechanisms
intestinal manipulation
knockout mice
postoperative ileus
steroid receptor coactivator-3
Journal
Inflammation
ISSN: 1573-2576
Titre abrégé: Inflammation
Pays: United States
ID NLM: 7600105
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
25
08
2020
accepted:
22
12
2020
revised:
09
12
2020
pubmed:
6
1
2021
medline:
15
12
2021
entrez:
5
1
2021
Statut:
ppublish
Résumé
Inflammation theory has suggested that the pathogenesis of postoperative ileus (POI) involves the steroid receptor coactivator-3 (SRC-3). Therefore, we investigated the role of SRC-3 in the muscles of the small intestine using a mouse POI model. Here, we reported that intestinal manipulation (IM) significantly reduced the extent of phenol red migration in the entire gastrointestinal tract, and the calculated geometric center (GC) value in wild-type (WT) mice at 24 h after surgery was higher than that in the knockout (KO) mice and in the sham-operated control group. The expression of SRC-3 was upregulated in the mouse intestinal muscularis at 24 h after surgical manipulation, and the mRNA and protein levels of inflammatory cytokines were upregulated compared with those in the control group. At 24 h after IM, the number of neutrophils in the experimental group was significantly higher than that in the control group; in the IM group, the number of neutrophils in the SRC-3
Identifiants
pubmed: 33398542
doi: 10.1007/s10753-020-01409-4
pii: 10.1007/s10753-020-01409-4
doi:
Substances chimiques
Cytokines
0
Inflammation Mediators
0
Peroxidase
EC 1.11.1.7
Ncoa3 protein, mouse
EC 2.3.1.48
Nuclear Receptor Coactivator 3
EC 2.3.1.48
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1145-1159Subventions
Organisme : National Natural Science Foundation of China
ID : 81601227
Organisme : National Natural Science Foundation of China
ID : 81970462
Organisme : Natural Science Foundation of Fujian Province
ID : 2016J05203
Organisme : Natural Science Foundation of Fujian Province
ID : 2015J01548
Organisme : the Science and Technology Planning Projects of Xiamen Science & Technology Bureau
ID : 3502Z20154008
Organisme : the Science and Technology Planning Projects of Xiamen Health and Family Planning Commission
ID : 3502Z20149004
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