Abnormal nuchal translucency followed by normal microarray analysis is associated with placental pathology-related complications.
chromosomal microarray analysis
fetus
nuchal translucency
placental complications
Journal
Prenatal diagnosis
ISSN: 1097-0223
Titre abrégé: Prenat Diagn
Pays: England
ID NLM: 8106540
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
revised:
22
12
2020
received:
13
11
2020
accepted:
31
12
2020
pubmed:
6
1
2021
medline:
15
12
2021
entrez:
5
1
2021
Statut:
ppublish
Résumé
Identify placental pathology-related complications, labor and neonatal outcomes in pregnancies complicated by pathological nuchal translucency (NT) with normal microarray analysis. A retrospective study in which all women with singleton pregnancy who demonstrated NT above 3 mm and a normal microarray analysis were matched to women with normal NT and a normal microarray analysis (2013-2019) in a single tertiary academic center. The following placental pathology-related parameters were measured: preeclampsia, oligohydramnios, suspected intrauterine growth restriction, abnormal Doppler studies or small for gestational age (SGA) neonates. The primary outcome was defined as a composite of complications related to placental pathology including preeclampsia and SGA neonate. Secondary outcomes were labor complications and neonatal morbidity. A total of 185 women were included in the study: of them, 47 presented an abnormal NT (study group) and 138 presented normal NT (controls). Groups did not significantly differ in baseline characteristics. Regarding primary outcome, all placental-related complications frequencies were higher in the study group, with a composite rate of 17.02% versus 6.52% in controls (p = 0.042%). Secondary outcomes did not differ between groups. Abnormal NT measurement presented in pregnancies with normal fetal microarray analysis is associated with higher rates of placental-related complications.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
855-860Informations de copyright
© 2021 John Wiley & Sons Ltd.
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