Blockade of orexin receptors in the ventral tegmental area reduced the extinction period of the lateral hypothalamic-induced conditioned place preference in rats.
Animals
Benzoxazoles
/ administration & dosage
Carbachol
/ pharmacology
Cholinergic Agonists
/ pharmacology
Conditioning, Classical
/ drug effects
Dose-Response Relationship, Drug
Hypothalamic Area, Lateral
/ drug effects
Isoquinolines
/ administration & dosage
Male
Naphthyridines
/ administration & dosage
Orexin Receptor Antagonists
/ administration & dosage
Orexin Receptors
/ drug effects
Pyridines
/ administration & dosage
Rats
Rats, Wistar
Reward
Urea
/ administration & dosage
Ventral Tegmental Area
/ drug effects
Journal
Behavioural pharmacology
ISSN: 1473-5849
Titre abrégé: Behav Pharmacol
Pays: England
ID NLM: 9013016
Informations de publication
Date de publication:
01 02 2021
01 02 2021
Historique:
pubmed:
6
1
2021
medline:
15
12
2021
entrez:
5
1
2021
Statut:
ppublish
Résumé
The orexinergic connection between the lateral hypothalamus (LH) and the ventral tegmental area (VTA) is involved in modulating the reward circuit. The conditioned place preference (CPP) can be induced by microinjection of carbachol, a cholinergic agonist, into the LH. The current research was conducted to understand whether intra-VTA orexin receptors (OXRs) could influence the duration of the extinction period or maintenance of the intra-LH carbachol-induced CPP. To this end, the rats unilaterally received intra-LH carbachol (250 nM) within a 3-day conditioning period. Animals that have already passed the conditioning test were unilaterally administered by intra-VTA microinjection of SB334867, an OX1R antagonist, or TCS OX2 29, an OX2R antagonist during the extinction phase of the LH stimulation-induced CPP. For the first time, our data indicated that daily intra-VTA administration of either SB334867 (30 nM) or TCS OX2 29 (10 and 30 nM) during the extinction period decreased the maintenance of intra-LH carbachol-induced CPP. In conclusion, OXRs in the VTA play crucial roles in the maintenance of reward processes.
Identifiants
pubmed: 33399296
doi: 10.1097/FBP.0000000000000602
pii: 00008877-202102000-00007
doi:
Substances chimiques
1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea
0
1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-((4-pyridinylmethyl)amino)-1-butanone
0
Benzoxazoles
0
Cholinergic Agonists
0
Isoquinolines
0
Naphthyridines
0
Orexin Receptor Antagonists
0
Orexin Receptors
0
Pyridines
0
Urea
8W8T17847W
Carbachol
8Y164V895Y
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
54-61Informations de copyright
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
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