Preliminary national report on cystic fibrosis epidemiology in Tunisia: the actual state of affairs.
Cystic fibrosis epidemiology
Tunisia
Journal
African health sciences
ISSN: 1729-0503
Titre abrégé: Afr Health Sci
Pays: Uganda
ID NLM: 101149451
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
entrez:
6
1
2021
pubmed:
7
1
2021
medline:
23
2
2021
Statut:
ppublish
Résumé
To establish a preliminary national report on clinical and genetic features of cystic fibrosis (CF) in Tunisian children as a first measure for a better health care organization. All children with CF diagnosed by positive sweat tests between 1996 and 2015 in children's departments of Tunisian university hospitals were included. Data was recorded at diagnosis and during the follow-up from patients' medical records. In 12 departments, 123 CF children were collected. The median age at diagnosis was 5 months with a median diagnosis delay of 3 months. CF was revealed mostly by recurrent respiratory tract infections (69.9%), denutrition (55.2%), and/or chronic diarrhea (41.4%). The mean sweat chloride concentration was 110.9mmol/L. At least one mutation was found in 95 cases (77.2%). The most frequent mutations were Phe508del (n=58) and E1104X (n=15). Fifty-five patients had a CF is life-shortening in Tunisia. Setting-up appropriate management is urgent.
Identifiants
pubmed: 33402933
doi: 10.4314/ahs.v20i1.51
pii: jAFHS.v20.i1.pg444
pmc: PMC7750075
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
444-452Informations de copyright
© 2020 Hamouda S et al.
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