Extratubular Polymerized Uromodulin Induces Leukocyte Recruitment and Inflammation
damage associated molecular pattern (DAMP)
inflammation
kidney disease
leukocyte recruitment
uromodulin
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
28
07
2020
accepted:
17
11
2020
entrez:
8
1
2021
pubmed:
9
1
2021
medline:
17
7
2021
Statut:
epublish
Résumé
Uromodulin (UMOD) is produced and secreted by tubular epithelial cells. Secreted UMOD polymerizes (pUMOD) in the tubular lumen, where it regulates salt transport and protects the kidney from bacteria and stone formation. Under various pathological conditions, pUMOD accumulates within the tubular lumen and reaches extratubular sites where it may interact with renal interstitial cells. Here, we investigated the potential of extratubular pUMOD to act as a damage associated molecular pattern (DAMP) molecule thereby creating local inflammation. We found that intrascrotal and intraperitoneal injection of pUMOD induced leukocyte recruitment
Identifiants
pubmed: 33414784
doi: 10.3389/fimmu.2020.588245
pmc: PMC7783395
doi:
Substances chimiques
Cell Adhesion Molecules
0
Uromodulin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
588245Informations de copyright
Copyright © 2020 Immler, Lange-Sperandio, Steffen, Beck, Rohwedder, Roth, Napoli, Hupel, Pfister, Popper, Uhl, Mannell, Reichel, Vielhauer, Scherberich, Sperandio and Pruenster.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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