Mass spectrometry-based characterization of histones in clinical samples: applications, progress, and challenges.
Antineoplastic Agents
/ therapeutic use
Chromatin
/ chemistry
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
Histones
/ genetics
Humans
Mass Spectrometry
/ methods
Neoplasm Proteins
/ genetics
Neoplasms
/ diagnosis
Peptide Mapping
/ methods
Peptides
/ analysis
Protein Processing, Post-Translational
Proteomics
biomarker
cancer
chromatin
epigenetics
histone post-translational modification
histone variant
histone-modifying enzyme
mass spectrometry
proteomics
Journal
The FEBS journal
ISSN: 1742-4658
Titre abrégé: FEBS J
Pays: England
ID NLM: 101229646
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
revised:
24
11
2020
received:
01
09
2020
accepted:
06
01
2021
pubmed:
9
1
2021
medline:
9
3
2022
entrez:
8
1
2021
Statut:
ppublish
Résumé
In the last 15 years, increasing evidence linking epigenetics to various aspects of cancer biology has prompted the investigation of histone post-translational modifications (PTMs) and histone variants in the context of clinical samples. The studies performed so far demonstrated the potential of this type of investigations for the discovery of both potential epigenetic biomarkers for patient stratification and novel epigenetic mechanisms potentially targetable for cancer therapy. Although traditionally the analysis of histones in clinical samples was performed through antibody-based methods, mass spectrometry (MS) has emerged as a more powerful tool for the unbiased, comprehensive, and quantitative investigation of histone PTMs and variants. MS has been extensively used for the analysis of epigenetic marks in cell lines and animal tissue and, thanks to recent technological advances, is now ready to be applied also to clinical samples. In this review, we will provide an overview on the quantitative MS-based analysis of histones, their PTMs and their variants in cancer clinical samples, highlighting current achievements and future perspectives for this novel field of research. Among the different MS-based approaches currently available for histone PTM profiling, we will focus on the 'bottom-up' strategy, namely the analysis of short proteolytic peptides, as it has been already successfully employed for the analysis of clinical samples.
Identifiants
pubmed: 33415821
doi: 10.1111/febs.15707
pmc: PMC9291046
doi:
Substances chimiques
Antineoplastic Agents
0
Chromatin
0
Histones
0
Neoplasm Proteins
0
Peptides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1191-1213Informations de copyright
© 2021 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
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