Roberta Noberini

Affiliations

Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.

Publications (31)

Mass spectrometry-based characterization of histones in clinical samples: applications, progress, and challenges.

The FEBS journal

Avec: Roberta Noberini , Giulia Robusti , Tiziana Bonaldi

Spatial epi-proteomics enabled by histone post-translational modification analysis from low-abundance clinical samples.

Clinical epigenetics

Avec: Roberta Noberini , Evelyn Oliva Savoia , Stefania Brandini , Francesco Greco , Francesca Marra , Giovanni Bertalot , Giancarlo Pruneri , Liam A McDonnell , Tiziana Bonaldi

Small molecule-induced epigenomic reprogramming of APL blasts leading to antiviral-like response and c-MYC downregulation.

Cancer gene therapy

Avec: Stefano Amatori , Giuseppe Persico , Francesco Cantatore , Martina Rusin , Mauro Formica , Luca Giorgi , Eleonora Macedi , Francesca Casciaro , Alfredo Errico Provenzano , Stefano Gambardella , Roberta Noberini , Tiziana Bonaldi , Vieri Fusi , Marco Giorgio , Mirco Fanelli

Investigating pathological epigenetic aberrations by epi-proteomics.

Clinical epigenetics

Avec: Giulia Robusti , Alessandro Vai , Tiziana Bonaldi , Roberta Noberini

Profiling of Epigenetic Features in Clinical Samples Reveals Novel Widespread Changes in Cancer.

Cancers

Avec: Roberta Noberini , Camilla Restellini , Evelyn Oliva Savoia , Francesco Raimondi , Lavinia Ghiani , Maria Giovanna Jodice , Giovanni Bertalot , Giuseppina Bonizzi , Maria Capra , Fausto Antonio Maffini , Marta Tagliabue , Mohssen Ansarin , Michela Lupia , Marco Giordano , Daniela Osti , Giuliana Pelicci , Susanna Chiocca , Tiziana Bonaldi

hSWATH: Unlocking SWATH's Full Potential for an Untargeted Histone Perspective.

Journal of proteome research

Avec: Laura De Clerck , Sander Willems , Roberta Noberini , Camilla Restellini , Bart Van Puyvelde , Simon Daled , Tiziana Bonaldi , Dieter Deforce , Maarten Dhaenens

Epigenetic drug target deconvolution by mass spectrometry-based technologies.

Nature structural & molecular biology

Avec: Roberta Noberini , Tiziana Bonaldi

The histone code of the fungal genus

Microbial genomics

Avec: Xin Zhang , Roberta Noberini , Tiziana Bonaldi , Jerome Collemare , Michael F Seidl

A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide.

Clinical epigenetics

Avec: Prodromos Chatzikyriakou , Dimitria Brempou , Mark Quinn , Lauren Fishbein , Roberta Noberini , Ioannis N Anastopoulos , Nicola Tufton , Eugenie S Lim , Rupert Obholzer , Johnathan G Hubbard , Mufaddal Moonim , Tiziana Bonaldi , Katherine L Nathanson , Louise Izatt , Rebecca J Oakey

Improved Mass Spectrometry-based methods reveal abundant propionylation and tissue specific histone propionylation profiles.

Molecular & cellular proteomics : MCP

Avec: Alessandro Vai , Roberta Noberini , Chiara Ghirardi , Dieggo Rodrigues de Paula , Michele Carminati , Rani Pallavi , Nathália Araújo , Patrick Varga-Weisz , Tiziana Bonaldi

Enrichment of histones from patient samples for mass spectrometry-based analysis of post-translational modifications.

Methods (San Diego, Calif.)

Avec: Roberta Noberini , Camilla Restellini , Evelyn Oliva Savoia , Tiziana Bonaldi

Alternative digestion approaches improve histone modification mapping by mass spectrometry in clinical samples.

Proteomics. Clinical applications

Avec: Camilla Restellini , Alessandro Cuomo , Michela Lupia , Marco Giordano , Tiziana Bonaldi , Roberta Noberini

Mass Spectrometry-Based Analysis of Histone Posttranslational Modifications from Laser Microdissected Samples.

Methods in molecular biology (Clifton, N.J.)

Avec: Roberta Noberini , Tiziana Bonaldi

Multi-omics integrative modelling for stereotactic body radiotherapy in early-stage non-small cell lung cancer: clinical trial protocol of the MONDRIAN study.

BMC cancer

Avec: Stefania Volpe , Mattia Zaffaroni , Gaia Piperno , Maria Giulia Vincini , Maria Alessia Zerella , Federico Mastroleo , Federica Cattani , Cristiana Iuliana Fodor , Federica Bellerba , Tiziana Bonaldi , Giuseppina Bonizzi , Francesco Ceci , Marta Cremonesi , Nicola Fusco , Sara Gandini , Cristina Garibaldi , Davide La Torre , Roberta Noberini , Giuseppe Petralia , Lorenzo Spaggiari , Konstantinos Venetis , Roberto Orecchia , Monica Casiraghi , Barbara Alicja Jereczek-Fossa

A truncated and catalytically inactive isoform of KDM5B histone demethylase accumulates in breast cancer cells and regulates H3K4 tri-methylation and gene expression.

Cancer gene therapy

Avec: Elena Di Nisio , Valerio Licursi , Cecilia Mannironi , Valentina Buglioni , Alessandro Paiardini , Giulia Robusti , Roberta Noberini , Tiziana Bonaldi , Rodolfo Negri

Activation of endogenous retroviruses and induction of viral mimicry by MEK1/2 inhibition in pancreatic cancer.

Science advances

Avec: Alice Cortesi , Francesco Gandolfi , Fabiana Arco , Pierluigi Di Chiaro , Emanuele Valli , Sara Polletti , Roberta Noberini , Francesco Gualdrini , Sergio Attanasio , Francesca Citron , I-Lin Ho , Rutvi Shah , Er-Yen Yen , Mara Cetty Spinella , Simona Ronzoni , Simona Rodighiero , Nico Mitro , Tiziana Bonaldi , Serena Ghisletti , Silvia Monticelli , Andrea Viale , Giuseppe Riccardo Diaferia , Gioacchino Natoli

Anticancer innovative therapy congress: Highlights from the 10th anniversary edition.

Cytokine & growth factor reviews

Avec: Francesca De Santis , Giovanni Fucà , Dirk Schadendorf , Alberto Mantovani , Luca Magnani , Michael Lisanti , Stephen Pettitt , Matteo Bellone , Giannino Del Sal , Saverio Minucci , Alexander Eggermont , Paolo Bruzzi , Silvio Bicciato , Pierfranco Conte , Roberta Noberini , John Hiscott , Filippo De Braud , Michele Del Vecchio , Massimo Di Nicola

LSD1-directed therapy affects glioblastoma tumorigenicity by deregulating the protective ATF4-dependent integrated stress response.

Science translational medicine

Avec: Stefania Faletti , Daniela Osti , Elena Ceccacci , Cristina Richichi , Brunella Costanza , Luciano Nicosia , Roberta Noberini , Giulia Marotta , Laura Furia , Mario R Faretta , Silvia Brambillasca , Micaela Quarto , Luca Bertero , Renzo Boldorini , Bianca Pollo , Sara Gandini , Davide Cora , Saverio Minucci , Ciro Mercurio , Mario Varasi , Tiziana Bonaldi , Giuliana Pelicci

Hyperacetylated histone H4 is a source of carbon contributing to lipid synthesis.

The EMBO journal

Avec: Evelina Charidemou , Roberta Noberini , Chiara Ghirardi , Polymnia Georgiou , Panayiota Marcou , Andria Theophanous , Katerina Strati , Hector Keun , Volker Behrends , Tiziana Bonaldi , Antonis Kirmizis

Acetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide.

Molecular cell

Avec: Marta Russo , Francesco Gualdrini , Veronica Vallelonga , Elena Prosperini , Roberta Noberini , Silvia Pedretti , Carolina Borriero , Pierluigi Di Chiaro , Sara Polletti , Gabriele Imperato , Mattia Marenda , Chiara Ghirardi , Fabio Bedin , Alessandro Cuomo , Simona Rodighiero , Tiziana Bonaldi , Nico Mitro , Serena Ghisletti , Gioacchino Natoli

Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells.

Cancer discovery

Avec: Dalia Rosano , Emre Sofyali , Heena Dhiman , Chiara Ghirardi , Diana Ivanoiu , Timon Heide , Andrea Vingiani , Alessia Bertolotti , Giancarlo Pruneri , Eleonora Canale , Hannah F Dewhurst , Debjani Saha , Neil Slaven , Iros Barozzi , Tong Li , Grigory Zemlyanskiy , Henry Phillips , Chela James , Balázs Győrffy , Claire Lynn , George D Cresswell , Farah Rehman , Roberta Noberini , Tiziana Bonaldi , Andrea Sottoriva , Luca Magnani

Advances in enrichment methods for mass spectrometry-based proteomics analysis of post-translational modifications.

Journal of chromatography. A

Avec: Jessica Brandi , Roberta Noberini , Tiziana Bonaldi , Daniela Cecconi

Serum proteomics profiling identifies a preliminary signature for the diagnosis of early-stage lung cancer.

Proteomics. Clinical applications

Avec: Roberto Gasparri , Roberta Noberini , Alessandro Cuomo , Avinash Yadav , Davide Tricarico , Carola Salvetto , Patrick Maisonneuve , Valentina Caminiti , Giulia Sedda , Angela Sabalic , Tiziana Bonaldi , Lorenzo Spaggiari

Clinical Application of Mass Spectrometry-Based Proteomics in Lung Cancer Early Diagnosis.

Proteomics. Clinical applications

Avec: Roberto Gasparri , Giulia Sedda , Roberta Noberini , Tiziana Bonaldi , Lorenzo Spaggiari

Label-Free Mass Spectrometry-Based Quantification of Linker Histone H1 Variants in Clinical Samples.

International journal of molecular sciences

Avec: Roberta Noberini , Cristina Morales Torres , Evelyn Oliva Savoia , Stefania Brandini , Maria Giovanna Jodice , Giovanni Bertalot , Giuseppina Bonizzi , Maria Capra , Giuseppe Diaferia , Paola Scaffidi , Tiziana Bonaldi

Intestinal differentiation involves cleavage of histone H3 N-terminal tails by multiple proteases.

Nucleic acids research

Avec: Karin Johanna Ferrari , Simona Amato , Roberta Noberini , Cecilia Toscani , Daniel Fernández-Pérez , Alessandra Rossi , Pasquale Conforti , Marika Zanotti , Tiziana Bonaldi , Simone Tamburri , Diego Pasini

Proteomics contributions to epigenetic drug discovery.

Proteomics

Avec: Roberta Noberini , Tiziana Bonaldi

A Super-SILAC Approach for Profiling Histone Posttranslational Modifications.

Methods in molecular biology (Clifton, N.J.)

Avec: Roberta Noberini , Elisa Longhi , Tiziana Bonaldi

Detection and quantification of the histone code in the fungal genus Aspergillus.

Fungal genetics and biology : FG & B

Avec: Xin Zhang , Roberta Noberini , Alessandro Vai , Tiziana Bonaldi , Michael F Seidl , Jérȏme Collemare

Mass Spectrometry-Based Profiling of Histone Post-Translational Modifications in Uveal Melanoma Tissues, Human Melanocytes, and Uveal Melanoma Cell Lines - A Pilot Study.

Investigative ophthalmology & visual science

Avec: Martina C Herwig-Carl , Amit Sharma , Verena Tischler , Natalie Pelusi , Karin U Loeffler , Frank G Holz , Michael Zeschnigk , Solange Landreville , Claudia Auw-Haedrich , Roberta Noberini , Tiziana Bonaldi

Multiscale modeling uncovers 7q11.23 copy number variation-dependent changes in ribosomal biogenesis and neuronal maturation and excitability.

The Journal of clinical investigation

Avec: Marija Mihailovich , Pierre-Luc Germain , Reinald Shyti , Davide Pozzi , Roberta Noberini , Yansheng Liu , Davide Aprile , Erika Tenderini , Flavia Troglio , Sebastiano Trattaro , Sonia Fabris , Ummi Ciptasari , Marco Tullio Rigoli , Nicolò Caporale , Giuseppe D'Agostino , Filippo Mirabella , Alessandro Vitriolo , Daniele Capocefalo , Adrianos Skaros , Agnese Virginia Franchini , Sara Ricciardi , Ida Biunno , Antonino Neri , Nael Nadif Kasri , Tiziana Bonaldi , Rudolf Aebersold , Michela Matteoli , Giuseppe Testa

Réseau de co-auteurs

Tiziana Bonaldi 30 collaborations

Evelyn Oliva Savoia 4 collaborations

Camilla Restellini 4 collaborations

Chiara Ghirardi 4 collaborations

Giulia Robusti 3 collaborations

Giovanni Bertalot 3 collaborations

Alessandro Vai 3 collaborations

Giuseppina Bonizzi 3 collaborations

Alessandro Cuomo 3 collaborations

Lorenzo Spaggiari 3 collaborations

Stefania Brandini 2 collaborations

Giancarlo Pruneri 2 collaborations

Maria Giovanna Jodice 2 collaborations

Maria Capra 2 collaborations

Michela Lupia 2 collaborations

Marco Giordano 2 collaborations

Daniela Osti 2 collaborations

Giuliana Pelicci 2 collaborations

Xin Zhang 2 collaborations

Michael F Seidl 2 collaborations

Sara Gandini 2 collaborations

Pierluigi Di Chiaro 2 collaborations

Sara Polletti 2 collaborations

Francesco Gualdrini 2 collaborations

Simona Rodighiero 2 collaborations

Nico Mitro 2 collaborations

Serena Ghisletti 2 collaborations

Gioacchino Natoli 2 collaborations

Luca Magnani 2 collaborations

Saverio Minucci 2 collaborations

Roberto Gasparri 2 collaborations

Giulia Sedda 2 collaborations

Francesco Greco 1 collaboration

Francesca Marra 1 collaboration

Liam A McDonnell 1 collaboration

Stefano Amatori 1 collaboration

Giuseppe Persico 1 collaboration

Francesco Cantatore 1 collaboration

Martina Rusin 1 collaboration

Mauro Formica 1 collaboration

Luca Giorgi 1 collaboration

Eleonora Macedi 1 collaboration

Francesca Casciaro 1 collaboration

Alfredo Errico Provenzano 1 collaboration

Stefano Gambardella 1 collaboration

Vieri Fusi 1 collaboration

Marco Giorgio 1 collaboration

Mirco Fanelli 1 collaboration

Francesco Raimondi 1 collaboration

Lavinia Ghiani 1 collaboration

Fausto Antonio Maffini 1 collaboration

Marta Tagliabue 1 collaboration

Mohssen Ansarin 1 collaboration

Susanna Chiocca 1 collaboration

Laura De Clerck 1 collaboration

Sander Willems 1 collaboration

Bart Van Puyvelde 1 collaboration

Simon Daled 1 collaboration

Dieter Deforce 1 collaboration

Maarten Dhaenens 1 collaboration

Jerome Collemare 1 collaboration

Prodromos Chatzikyriakou 1 collaboration

Dimitria Brempou 1 collaboration

Mark Quinn 1 collaboration

Lauren Fishbein 1 collaboration

Ioannis N Anastopoulos 1 collaboration

Nicola Tufton 1 collaboration

Eugenie S Lim 1 collaboration

Rupert Obholzer 1 collaboration

Johnathan G Hubbard 1 collaboration

Mufaddal Moonim 1 collaboration

Katherine L Nathanson 1 collaboration

Louise Izatt 1 collaboration

Rebecca J Oakey 1 collaboration

Dieggo Rodrigues de Paula 1 collaboration

Michele Carminati 1 collaboration

Rani Pallavi 1 collaboration

Nathália Araújo 1 collaboration

Patrick Varga-Weisz 1 collaboration

Stefania Volpe 1 collaboration

Mattia Zaffaroni 1 collaboration

Gaia Piperno 1 collaboration

Maria Giulia Vincini 1 collaboration

Maria Alessia Zerella 1 collaboration

Federico Mastroleo 1 collaboration

Federica Cattani 1 collaboration

Cristiana Iuliana Fodor 1 collaboration

Federica Bellerba 1 collaboration

Francesco Ceci 1 collaboration

Marta Cremonesi 1 collaboration

Nicola Fusco 1 collaboration

Cristina Garibaldi 1 collaboration

Davide La Torre 1 collaboration

Giuseppe Petralia 1 collaboration

Konstantinos Venetis 1 collaboration

Roberto Orecchia 1 collaboration

Monica Casiraghi 1 collaboration

Barbara Alicja Jereczek-Fossa 1 collaboration

Elena Di Nisio 1 collaboration

Valerio Licursi 1 collaboration

Cecilia Mannironi 1 collaboration

Valentina Buglioni 1 collaboration

Alessandro Paiardini 1 collaboration

Rodolfo Negri 1 collaboration

Alice Cortesi 1 collaboration

Francesco Gandolfi 1 collaboration

Fabiana Arco 1 collaboration

Emanuele Valli 1 collaboration

Sergio Attanasio 1 collaboration

Francesca Citron 1 collaboration

I-Lin Ho 1 collaboration

Rutvi Shah 1 collaboration

Er-Yen Yen 1 collaboration

Mara Cetty Spinella 1 collaboration

Simona Ronzoni 1 collaboration

Silvia Monticelli 1 collaboration

Andrea Viale 1 collaboration

Giuseppe Riccardo Diaferia 1 collaboration

Francesca De Santis 1 collaboration

Giovanni Fucà 1 collaboration

Dirk Schadendorf 1 collaboration

Alberto Mantovani 1 collaboration

Michael Lisanti 1 collaboration

Stephen Pettitt 1 collaboration

Matteo Bellone 1 collaboration

Giannino Del Sal 1 collaboration

Alexander Eggermont 1 collaboration

Paolo Bruzzi 1 collaboration

Silvio Bicciato 1 collaboration

Pierfranco Conte 1 collaboration

John Hiscott 1 collaboration

Filippo De Braud 1 collaboration

Michele Del Vecchio 1 collaboration

Massimo Di Nicola 1 collaboration

Stefania Faletti 1 collaboration

Elena Ceccacci 1 collaboration

Cristina Richichi 1 collaboration

Brunella Costanza 1 collaboration

Luciano Nicosia 1 collaboration

Giulia Marotta 1 collaboration

Laura Furia 1 collaboration

Mario R Faretta 1 collaboration

Silvia Brambillasca 1 collaboration

Micaela Quarto 1 collaboration

Luca Bertero 1 collaboration

Renzo Boldorini 1 collaboration

Bianca Pollo 1 collaboration

Davide Cora 1 collaboration

Ciro Mercurio 1 collaboration

Mario Varasi 1 collaboration

Evelina Charidemou 1 collaboration

Polymnia Georgiou 1 collaboration

Panayiota Marcou 1 collaboration

Andria Theophanous 1 collaboration

Katerina Strati 1 collaboration

Hector Keun 1 collaboration

Volker Behrends 1 collaboration

Antonis Kirmizis 1 collaboration

Marta Russo 1 collaboration

Veronica Vallelonga 1 collaboration

Elena Prosperini 1 collaboration

Silvia Pedretti 1 collaboration

Carolina Borriero 1 collaboration

Gabriele Imperato 1 collaboration

Mattia Marenda 1 collaboration

Fabio Bedin 1 collaboration

Dalia Rosano 1 collaboration

Emre Sofyali 1 collaboration

Heena Dhiman 1 collaboration

Diana Ivanoiu 1 collaboration

Timon Heide 1 collaboration

Andrea Vingiani 1 collaboration

Alessia Bertolotti 1 collaboration

Eleonora Canale 1 collaboration

Hannah F Dewhurst 1 collaboration

Debjani Saha 1 collaboration

Neil Slaven 1 collaboration

Iros Barozzi 1 collaboration

Tong Li 1 collaboration

Grigory Zemlyanskiy 1 collaboration

Henry Phillips 1 collaboration

Chela James 1 collaboration

Balázs Győrffy 1 collaboration

Claire Lynn 1 collaboration

George D Cresswell 1 collaboration

Farah Rehman 1 collaboration

Andrea Sottoriva 1 collaboration

Jessica Brandi 1 collaboration

Daniela Cecconi 1 collaboration

Avinash Yadav 1 collaboration

Davide Tricarico 1 collaboration

Carola Salvetto 1 collaboration

Patrick Maisonneuve 1 collaboration

Valentina Caminiti 1 collaboration

Angela Sabalic 1 collaboration

Cristina Morales Torres 1 collaboration

Giuseppe Diaferia 1 collaboration

Paola Scaffidi 1 collaboration

Karin Johanna Ferrari 1 collaboration

Simona Amato 1 collaboration

Cecilia Toscani 1 collaboration

Daniel Fernández-Pérez 1 collaboration

Alessandra Rossi 1 collaboration

Pasquale Conforti 1 collaboration

Marika Zanotti 1 collaboration

Simone Tamburri 1 collaboration

Diego Pasini 1 collaboration

Elisa Longhi 1 collaboration

Jérȏme Collemare 1 collaboration

Martina C Herwig-Carl 1 collaboration

Amit Sharma 1 collaboration

Verena Tischler 1 collaboration

Natalie Pelusi 1 collaboration

Karin U Loeffler 1 collaboration

Frank G Holz 1 collaboration

Michael Zeschnigk 1 collaboration

Solange Landreville 1 collaboration

Claudia Auw-Haedrich 1 collaboration

Marija Mihailovich 1 collaboration

Pierre-Luc Germain 1 collaboration

Reinald Shyti 1 collaboration

Davide Pozzi 1 collaboration

Yansheng Liu 1 collaboration

Davide Aprile 1 collaboration

Erika Tenderini 1 collaboration

Flavia Troglio 1 collaboration

Sebastiano Trattaro 1 collaboration

Sonia Fabris 1 collaboration

Ummi Ciptasari 1 collaboration

Marco Tullio Rigoli 1 collaboration

Nicolò Caporale 1 collaboration

Giuseppe D'Agostino 1 collaboration

Filippo Mirabella 1 collaboration

Alessandro Vitriolo 1 collaboration

Daniele Capocefalo 1 collaboration

Adrianos Skaros 1 collaboration

Agnese Virginia Franchini 1 collaboration

Sara Ricciardi 1 collaboration

Ida Biunno 1 collaboration

Antonino Neri 1 collaboration

Nael Nadif Kasri 1 collaboration

Rudolf Aebersold 1 collaboration

Michela Matteoli 1 collaboration

Giuseppe Testa 1 collaboration