Cranial Suture Regeneration Mitigates Skull and Neurocognitive Defects in Craniosynostosis.

Animals Behavior, Animal / drug effects Cognition / drug effects Cranial Sutures / physiopathology Craniosynostoses / genetics Dura Mater / pathology Gelatin / pharmacology Gene Expression Profiling Hand Strength Intracranial Pressure / drug effects Locomotion / drug effects Mesenchymal Stem Cells / drug effects Methacrylates / pharmacology Mice, Inbred C57BL Motor Activity / drug effects Organ Size / drug effects Regeneration / drug effects Skull / pathology Twist-Related Protein 1 / metabolism Wnt Signaling Pathway / drug effects
Twist1 calvarial deformity mesenchymal stem cells neurocognitive abnormalities suture regeneration

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
07 01 2021
Historique:
received: 16 03 2020
revised: 28 07 2020
accepted: 16 11 2020
entrez: 8 1 2021
pubmed: 9 1 2021
medline: 26 8 2021
Statut: ppublish

Résumé

Craniosynostosis results from premature fusion of the cranial suture(s), which contain mesenchymal stem cells (MSCs) that are crucial for calvarial expansion in coordination with brain growth. Infants with craniosynostosis have skull dysmorphology, increased intracranial pressure, and complications such as neurocognitive impairment that compromise quality of life. Animal models recapitulating these phenotypes are lacking, hampering development of urgently needed innovative therapies. Here, we show that Twist1

Identifiants

DOI: 10.1016/j.cell.2020.11.037 PMID: 33417861 PMC: PMC7891303
pubmed: 33417861
pii: S0092-8674(20)31609-3
doi: 10.1016/j.cell.2020.11.037
pmc: PMC7891303
mid: NIHMS1649370
pii:
doi:

Substances chimiques

Methacrylates 0
Twist-Related Protein 1 0
Twist1 protein, mouse 136253-27-5
methacrylic acid 1CS02G8656
Gelatin 9000-70-8

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

243-256.e18

Subventions

Organisme : NIA NIH HHS
ID : R01 AG061288
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE026339
Pays : United States
Organisme : NICHD NIH HHS
ID : K12 HD051958
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE012711
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS097231
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS110687
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE022503
Pays : United States
Organisme : NIDCR NIH HHS
ID : U24 DE026914
Pays : United States
Organisme : NIA NIH HHS
ID : R03 AG063287
Pays : United States
Organisme : NIDCR NIH HHS
ID : U24 DE029463
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

Références

Nat Med. 2011 Nov 20;17(12):1594-601
pubmed: 22101767
Plast Reconstr Surg. 2008 Jul;122(1):53-63
pubmed: 18594386
Bone Res. 2018 Oct 17;6:30
pubmed: 30345151
J Med Genet. 1997 Aug;34(8):632-6
pubmed: 9279753
J Histochem Cytochem. 2005 Oct;53(10):1181-7
pubmed: 15923362
Arch Dis Child. 2005 Apr;90(4):346-50
pubmed: 15781920
Childs Nerv Syst. 2007 Oct;23(10):1103-9
pubmed: 17486351
Development. 2005 Apr;132(8):1995-2005
pubmed: 15790973
J Neurosci Methods. 1995 Nov;62(1-2):15-9
pubmed: 8750080
Nat Protoc. 2013 Dec;8(12):2531-7
pubmed: 24263092
Birth Defects Res C Embryo Today. 2007 Dec;81(4):297-304
pubmed: 18228258
Dev Biol. 2015 Apr 15;400(2):180-90
pubmed: 25722190
Cell Physiol Biochem. 2014;33(4):905-19
pubmed: 24713626
Genes Brain Behav. 2002 Jan;1(1):55-69
pubmed: 12886950
Plast Reconstr Surg. 2008 Aug;122(2):389-399
pubmed: 18626354
Science. 2018 Dec 14;362(6420):
pubmed: 30545855
Dev Dyn. 2005 Jan;232(1):75-84
pubmed: 15543606
Biomacromolecules. 2000 Spring;1(1):31-8
pubmed: 11709840
Cell. 2018 Sep 20;175(1):43-56.e21
pubmed: 30241615
J Dev Behav Pediatr. 2016 Jul-Aug;37(6):483-90
pubmed: 27355879
J Vis Exp. 2015 May 05;(99):e52615
pubmed: 25992586
Am Fam Physician. 2004 Jun 15;69(12):2863-70
pubmed: 15222651
Traffic. 2012 Dec;13(12):1589-600
pubmed: 22984916
Anat Rec (Hoboken). 2014 May;297(5):826-33
pubmed: 24585549
Stem Cells Transl Med. 2013 Jan;2(1):33-42
pubmed: 23283490
Genes Dev. 1995 Mar 15;9(6):686-99
pubmed: 7729687
Pediatrics. 2015 Mar;135(3):e615-23
pubmed: 25713274
J Craniofac Surg. 2019 Jul;30(5):1506-1511
pubmed: 31299755
J Mol Neurosci. 2002 Feb-Apr;18(1-2):151-65
pubmed: 11931346
Mol Ecol Resour. 2011 Mar;11(2):353-7
pubmed: 21429143
Nat Rev Neurosci. 2007 Jun;8(6):427-37
pubmed: 17514196
J Neurosurg. 1982 Sep;57(3):370-7
pubmed: 7097333
Pharmacol Biochem Behav. 1978 Jan;8(1):101-2
pubmed: 625478
Front Neural Circuits. 2008 Oct 29;2:4
pubmed: 18989389
Trends Cogn Sci. 2009 Mar;13(3):103-9
pubmed: 19223228
Nat Cell Biol. 2015 Apr;17(4):386-96
pubmed: 25799059
Am J Hum Genet. 2015 Sep 3;97(3):359-77
pubmed: 26340332
Child Neuropsychol. 2017 Jan;23(1):83-98
pubmed: 26381123
Anal Biochem. 1966 Mar;14(3):328-36
pubmed: 4161471
J Anat. 2005 Nov;207(5):637-53
pubmed: 16313397
Nat Neurosci. 2017 Aug;20(8):1062-1073
pubmed: 28671691
J Vis Exp. 2012 Apr 25;(62):
pubmed: 22565931
Am J Med Genet A. 2012 Jul;158A(7):1680-5
pubmed: 22628249
Prog Neurobiol. 2013 Jul-Aug;106-107:1-16
pubmed: 23583307
J Craniofac Surg. 2018 Jan;29(1):49-55
pubmed: 29049144
Biomater Sci. 2017 Sep 26;5(10):2093-2105
pubmed: 28805830
Curr Opin Neurobiol. 2008 Feb;18(1):28-35
pubmed: 18508260
Plast Reconstr Surg. 2017 Dec;140(6):1235-1239
pubmed: 29176416
Acta Biomater. 2014 Jun;10(6):2551-62
pubmed: 24590158
J Dent Res. 2006 Nov;85(11):966-79
pubmed: 17062735
Plast Reconstr Surg. 1996 Feb;97(2):276-81
pubmed: 8559809
J Cell Physiol. 2019 Aug;234(10):17639-17648
pubmed: 30854680
J Korean Neurosurg Soc. 2016 May;59(3):242-6
pubmed: 27226855
Trends Cogn Sci. 2006 Mar;10(3):100-7
pubmed: 16469525
J Dent Res. 2015 Nov;94(11):1495-501
pubmed: 26350960
Cells Tissues Organs. 2004;176(1-3):54-66
pubmed: 14745235
Stem Cells Dev. 2016 Dec 1;25(23):1801-1807
pubmed: 27762665
Nat Commun. 2016 Feb 01;7:10526
pubmed: 26830436
Nat Biotechnol. 2004 May;22(5):560-7
pubmed: 15077117
Science. 2017 Nov 24;358(6366):1027-1032
pubmed: 29170230
J Craniofac Surg. 2019 Sep;30(6):1719-1723
pubmed: 31022138
Dev Biol. 2009 Jul 15;331(2):176-88
pubmed: 19414008
Hum Mutat. 2000;15(5):479
pubmed: 10790211
Pediatr Neurol Briefs. 2015 Jun;29(6):47
pubmed: 26933586

Auteurs

Mengfei Yu (M)

Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA; Key Laboratory of Oral Biomedical Research, Affiliated Stomatology Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Li Ma (L)

Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA.

Yuan Yuan (Y)

Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA.

Xin Ye (X)

Key Laboratory of Oral Biomedical Research, Affiliated Stomatology Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Axel Montagne (A)

Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, Los Angeles, CA 90033, USA.

Jinzhi He (J)

Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA.

Thach-Vu Ho (TV)

Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA.

Yingxi Wu (Y)

Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, Los Angeles, CA 90033, USA.

Zhen Zhao (Z)

Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, Los Angeles, CA 90033, USA.

Naomi Sta Maria (N)

Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, Los Angeles, CA 90033, USA.

Russell Jacobs (R)

Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, Los Angeles, CA 90033, USA.

Mark Urata (M)

Division of Plastic and Maxillofacial Surgery, Children's Hospital Los Angeles, Los Angeles, CA 90033, USA.

Huiming Wang (H)

Key Laboratory of Oral Biomedical Research, Affiliated Stomatology Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Berislav V Zlokovic (BV)

Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, Los Angeles, CA 90033, USA.

Jian-Fu Chen (JF)

Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA.

Yang Chai (Y)

Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA. Electronic address: ychai@usc.edu.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Cranial Suture Regeneration Mitigates Skull...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement animal › Cranial Suture Regeneration Mitigates Skull...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Cranial Suture Regeneration Mitigates Skull...
questionsmedicales.fr › Appareil locomoteur › Squelette › Crâne › Sutures crâniennes › Cranial Suture Regeneration Mitigates Skull...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Malformations › Malformations de l'appareil locomoteur › Synostose › Craniosynostoses › Cranial Suture Regeneration Mitigates Skull...
questionsmedicales.fr › Système nerveux › Système nerveux central › Méninges › Dure-mère › Cranial Suture Regeneration Mitigates Skull...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Gélatine › Cranial Suture Regeneration Mitigates Skull...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Cranial Suture Regeneration Mitigates Skull...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Force musculaire › Force de la main › Cranial Suture Regeneration Mitigates Skull...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Pression du liquide cérébrospinal › Pression intracrânienne › Cranial Suture Regeneration Mitigates Skull...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Mouvement › Locomotion › Cranial Suture Regeneration Mitigates Skull...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches multipotentes › Cellules souches mésenchymateuses › Cranial Suture Regeneration Mitigates Skull...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides acycliques › Acrylates › Méthacrylates › Cranial Suture Regeneration Mitigates Skull...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Cranial Suture Regeneration Mitigates Skull...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Mouvement › Activité motrice › Cranial Suture Regeneration Mitigates Skull...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Taille d'organe › Cranial Suture Regeneration Mitigates Skull...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Cranial Suture Regeneration Mitigates Skull...
questionsmedicales.fr › Appareil locomoteur › Squelette › Crâne › Cranial Suture Regeneration Mitigates Skull...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › Facteurs de transcription Twist › Protéine-1 apparentée à Twist › Cranial Suture Regeneration Mitigates Skull...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Voie de signalisation Wnt › Cranial Suture Regeneration Mitigates Skull...