Role of GTPases in Driving Mitoribosome Assembly.

GTP Phosphohydrolases / metabolism Mitochondria Mitochondrial Proteins / metabolism Mitochondrial Ribosomes / metabolism Ribosomal Proteins / metabolism
GTPBP OXPHOS deficiency mitochondrial diseases mitochondrial ribosome mitoribosome assembly GTPase quality control of mitoribosome maturation

Journal

Trends in cell biology
ISSN: 1879-3088
Titre abrégé: Trends Cell Biol
Pays: England
ID NLM: 9200566

Informations de publication

Date de publication:
04 2021
Historique:
received: 02 09 2020
revised: 01 12 2020
accepted: 11 12 2020
pubmed: 10 1 2021
medline: 15 12 2021
entrez: 9 1 2021
Statut: ppublish

Résumé

Mitoribosomes catalyze essential protein synthesis within mitochondria. Mitoribosome biogenesis is assisted by an increasing number of assembly factors, among which guanosine triphosphate hydrolases (GTPases) are the most abundant class. Here, we review recent progress in our understanding of mitoribosome assembly GTPases. We describe their shared and specific features and mechanisms of action, compare them with their bacterial counterparts, and discuss their possible roles in the assembly of small or large mitoribosomal subunits and the formation of the monosome by establishing quality-control checkpoints during these processes. Furthermore, following the recent unification of the nomenclature for the mitoribosomal proteins, we also propose a unified nomenclature for mitoribosome assembly GTPases.

Identifiants

DOI: 10.1016/j.tcb.2020.12.008 PMID: 33419649 PMC: PMC7954922
pubmed: 33419649
pii: S0962-8924(20)30254-3
doi: 10.1016/j.tcb.2020.12.008
pmc: PMC7954922
mid: NIHMS1658178
pii:
doi:

Substances chimiques

Mitochondrial Proteins 0
Ribosomal Proteins 0
GTP Phosphohydrolases EC 3.6.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

284-297

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM118141
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

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Auteurs

Priyanka Maiti (P)

Department of Neurology, University of Miami Miller School of Medicine, 1420 NW 9th Avenue, Neurology Research Building # 103B, Miami, FL 33136, USA.

Elena Lavdovskaia (E)

University Medical Center Göttingen, Department of Cellular Biochemistry, Humboldtallee 23, D-37073 Göttingen, Germany; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, D-37075, Göttingen, Germany.

Antoni Barrientos (A)

Department of Neurology, University of Miami Miller School of Medicine, 1420 NW 9th Avenue, Neurology Research Building # 103B, Miami, FL 33136, USA; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1600 NW 10th Avenue, RMSB # 2067, Miami, FL 33136, USA. Electronic address: abarrientos@med.miami.edu.

Ricarda Richter-Dennerlein (R)

University Medical Center Göttingen, Department of Cellular Biochemistry, Humboldtallee 23, D-37073 Göttingen, Germany; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, D-37075, Göttingen, Germany. Electronic address: ricarda.richter@med.uni-goettingen.de.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Acid anhydride hydrolases › dGTPases › Role of GTPases in Driving Mitoribosome Assembly.
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Role of GTPases in Driving Mitoribosome Assembly.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Role of GTPases in Driving Mitoribosome Assembly.
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Ribosomes › Ribosomes mitochondriaux › Role of GTPases in Driving Mitoribosome Assembly.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines ribosomiques › Role of GTPases in Driving Mitoribosome Assembly.