Build a Sustainable Vaccines Industry with Synthetic Biology.
biofoundry
distributed manufacturing
point of care
synthetic biology
vaccines
Journal
Trends in biotechnology
ISSN: 1879-3096
Titre abrégé: Trends Biotechnol
Pays: England
ID NLM: 8310903
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
20
10
2020
revised:
21
11
2020
accepted:
09
12
2020
pubmed:
13
1
2021
medline:
13
10
2021
entrez:
12
1
2021
Statut:
ppublish
Résumé
The vaccines industry has not changed appreciably in decades regarding technology, and has struggled to remain viable, with large companies withdrawing from production. Meanwhile, there has been no let-up in outbreaks of viral disease, at a time when the biopharmaceuticals industry is discussing downsizing. The distributed manufacturing model aligns well with this, and the advent of synthetic biology promises much in terms of vaccine design. Biofoundries separate design from manufacturing, a hallmark of modern engineering. Once designed in a biofoundry, digital code can be transferred to a small-scale manufacturing facility close to the point of care, rather than physically transferring cold-chain-dependent vaccine. Thus, biofoundries and distributed manufacturing have the potential to open up a new era of biomanufacturing, one based on digital biology and information systems. This seems a better model for tackling future outbreaks and pandemics.
Identifiants
pubmed: 33431228
pii: S0167-7799(20)30331-0
doi: 10.1016/j.tibtech.2020.12.006
pmc: PMC7834237
pii:
doi:
Substances chimiques
Biological Products
0
Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
866-874Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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