Fluid Biomarkers of Frontotemporal Lobar Degeneration.
Amyloid-β
Blood biomarker
Cerebrospinal fluid biomarker
Dipeptide repeat proteins
Neurofilament light chain
Progranulin
Tau
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
12
1
2021
pubmed:
13
1
2021
medline:
16
2
2021
Statut:
ppublish
Résumé
A timely diagnosis of frontotemporal degeneration (FTD) is frequently challenging due to the heterogeneous symptomatology and poor phenotype-pathological correlation. Fluid biomarkers that reflect FTD pathophysiology could be instrumental in both clinical practice and pharmaceutical trials. In recent years, significant progress has been made in developing biomarkers of neurodegenerative diseases: amyloid-β and tau in cerebrospinal fluid (CSF) can be used to exclude Alzheimer's disease, while neurofilament light chain (NfL) is emerging as a promising, albeit nonspecific, marker of neurodegeneration in both CSF and blood. Gene-specific biomarkers such as PGRN in GRN mutation carriers and dipeptide repeat proteins in C9orf72 mutation carriers are potential target engagement markers in genetic FTD trials. Novel techniques capable of measuring very low concentrations of brain-derived proteins in peripheral fluids are facilitating studies of blood biomarkers as a minimally invasive alternative to CSF. A major remaining challenge is the identification of a biomarker that can be used to predict the neuropathological substrate in sporadic FTD patients.
Identifiants
pubmed: 33433873
doi: 10.1007/978-3-030-51140-1_9
doi:
Substances chimiques
Amyloid beta-Peptides
0
Biomarkers
0
C9orf72 Protein
0
C9orf72 protein, human
0
Neurofilament Proteins
0
tau Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
123-139Références
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