Therapeutic Strategies for the Treatment of Chronic Hyperuricemia: An Evidence-Based Update.
Acetamides
/ therapeutic use
Allopurinol
/ therapeutic use
Benzbromarone
/ therapeutic use
Chronic Disease
Evidence-Based Medicine
Febuxostat
/ therapeutic use
Gout Suppressants
/ therapeutic use
Humans
Hyperuricemia
/ drug therapy
Naphthalenes
/ therapeutic use
Nitriles
/ therapeutic use
Phenylacetates
/ therapeutic use
Polyethylene Glycols
/ therapeutic use
Probenecid
/ therapeutic use
Propionates
/ therapeutic use
Pyridines
/ therapeutic use
Thioglycolates
/ therapeutic use
Triazoles
/ therapeutic use
Urate Oxidase
/ therapeutic use
Uricosuric Agents
/ therapeutic use
Xanthine Oxidase
/ antagonists & inhibitors
hyperuricemia
uric acid
uric acid-lowering drugs
uricosurics
xanthine oxidase inhibitors
Journal
Medicina (Kaunas, Lithuania)
ISSN: 1648-9144
Titre abrégé: Medicina (Kaunas)
Pays: Switzerland
ID NLM: 9425208
Informations de publication
Date de publication:
10 Jan 2021
10 Jan 2021
Historique:
received:
15
11
2020
revised:
30
12
2020
accepted:
07
01
2021
entrez:
13
1
2021
pubmed:
14
1
2021
medline:
20
1
2021
Statut:
epublish
Résumé
This article aims to critically review the evidence on the available therapeutic strategies for the treatment of hyperuricemia. For this reason, several papers were reviewed. Xanthine oxidase inhibitors are the safest and most effective uric acid lowering drugs for the management of chronic hyperuricemia, while the efficacy of uricosuric agents is strongly modulated by pharmacogenetics. Emergent drugs (lesinurad, peglotidase) were found to be more effective for the acute management of refractory hyperuricemia, but their use is supported by a relatively small number of clinical trials so that further well-designed clinical research is needed to deepen their efficacy and safety profile.
Identifiants
pubmed: 33435164
pii: medicina57010058
doi: 10.3390/medicina57010058
pmc: PMC7827966
pii:
doi:
Substances chimiques
Acetamides
0
Gout Suppressants
0
Naphthalenes
0
Nitriles
0
Phenylacetates
0
Propionates
0
Pyridines
0
Thioglycolates
0
Triazoles
0
Uricosuric Agents
0
lesinurad
09ERP08I3W
FYX-051
0J877412JV
Febuxostat
101V0R1N2E
verinurad
12WJ62D047
arhalofenate
1P01UJR9X1
Polyethylene Glycols
3WJQ0SDW1A
Benzbromarone
4POG0RL69O
Allopurinol
63CZ7GJN5I
Xanthine Oxidase
EC 1.17.3.2
Urate Oxidase
EC 1.7.3.3
Probenecid
PO572Z7917
Pegloticase
R581OT55EA
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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