questionsmedicales.fr
Actions chimiques et utilisations
Actions pharmacologiques
Utilisations thérapeutiques
Antirhumatismaux
Antigoutteux
Uricosuriques
Uricosuriques : Questions médicales fréquentes
Diagnostic
5
Hyperuricémie
Acide urique
Goutte
Analyse du liquide synovial
Uricosuriques
Acide urique
Hyperuricémie
Nodules de tophus
Symptômes
5
Goutte
Douleur articulaire
Traitements
5
Uricosuriques
Acide urique
Probénécide
Sulfinpyrazone
Effets secondaires
Calculs rénaux
Complications
5
Tophus
Déformation articulaire
Calculs rénaux
Acide urique
Facteurs de risque
5
Facteurs de risque
Goutte
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"name": "Comment évaluer l'efficacité des uricosuriques ?",
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"@type": "Question",
"name": "Quels signes cliniques sont associés à l'hyperuricémie ?",
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"@type": "Question",
"name": "Quels sont les symptômes de la goutte ?",
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"@type": "Question",
"name": "Comment prévenir les crises de goutte ?",
"position": 11,
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"@type": "Question",
"name": "Quels aliments éviter pour prévenir la goutte ?",
"position": 12,
"acceptedAnswer": {
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}
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"@type": "Question",
"name": "L'hydratation aide-t-elle à prévenir la goutte ?",
"position": 13,
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"@type": "Question",
"name": "Le poids corporel influence-t-il la goutte ?",
"position": 14,
"acceptedAnswer": {
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}
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{
"@type": "Question",
"name": "Les uricosuriques peuvent-ils être préventifs ?",
"position": 15,
"acceptedAnswer": {
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"text": "Oui, ils peuvent être utilisés en traitement préventif chez les patients à risque."
}
},
{
"@type": "Question",
"name": "Comment fonctionnent les agents uricosuriques ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils augmentent l'excrétion d'acide urique par les reins, réduisant ainsi son taux sanguin."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux agents uricosuriques ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les principaux incluent le probénécide et le sulfinpyrazone, utilisés pour la goutte."
}
},
{
"@type": "Question",
"name": "Quand utiliser des uricosuriques ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils sont utilisés lorsque les anti-inflammatoires ne suffisent pas pour contrôler la goutte."
}
},
{
"@type": "Question",
"name": "Quels effets secondaires des uricosuriques ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent causer des éruptions cutanées, des troubles gastro-intestinaux et des calculs rénaux."
}
},
{
"@type": "Question",
"name": "Les uricosuriques sont-ils efficaces pour tous ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, leur efficacité peut varier selon les individus et les causes de l'hyperuricémie."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec la goutte ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des lésions articulaires permanentes et des calculs rénaux."
}
},
{
"@type": "Question",
"name": "Les tophus sont-ils dangereux ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les tophus peuvent causer des douleurs et des déformations articulaires."
}
},
{
"@type": "Question",
"name": "Comment les calculs rénaux sont-ils liés à la goutte ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'excès d'acide urique peut former des cristaux, entraînant des calculs rénaux."
}
},
{
"@type": "Question",
"name": "La goutte peut-elle affecter d'autres organes ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut entraîner des problèmes rénaux et cardiovasculaires à long terme."
}
},
{
"@type": "Question",
"name": "Les crises de goutte peuvent-elles être invalidantes ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la douleur intense peut limiter les activités quotidiennes et la mobilité."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque de la goutte ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent l'obésité, une alimentation riche en purines, et l'hérédité."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il le risque de goutte ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque de goutte augmente avec l'âge, surtout chez les hommes après 40 ans."
}
},
{
"@type": "Question",
"name": "Le sexe joue-t-il un rôle dans la goutte ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les hommes sont plus susceptibles de développer la goutte que les femmes."
}
},
{
"@type": "Question",
"name": "Les médicaments peuvent-ils augmenter le risque de goutte ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains diurétiques et médicaments peuvent augmenter le taux d'acide urique."
}
},
{
"@type": "Question",
"name": "Le stress a-t-il un impact sur la goutte ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress peut déclencher des crises de goutte chez les personnes prédisposées."
}
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}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 15/03/2026
Contenu vérifié selon les dernières recommandations médicales
3 publications dans cette catégorie
Affiliations :
Faculty of Engineering Sciences, Kyushu University, Kasuga-koen, Kasuga-shi, Fukuoka 816-8580, Japan.
Publications dans "Uricosuriques" :
2 publications dans cette catégorie
Affiliations :
FUJI YAKUHIN CO., LTD. Saitama Japan.
Publications dans "Uricosuriques" :
2 publications dans cette catégorie
Affiliations :
FUJI YAKUHIN CO., LTD. Saitama Japan.
Publications dans "Uricosuriques" :
2 publications dans cette catégorie
Affiliations :
Faculty of Pharmaceutical Sciences Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Japan.
Publications dans "Uricosuriques" :
2 publications dans cette catégorie
Affiliations :
Guangdong Provincial Key Laboratory of Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
Publications dans "Uricosuriques" :
2 publications dans cette catégorie
Affiliations :
Department of Orthopaedics, Faculty of Medicine and Health Sciences Universiti Putra Malaysia Serdang Selangor Darul Ehsan Malaysia.
Hand & Upper Limb Centre Pantai Hospital Kuala Lumpur Kuala Lumpur Malaysia.
Publications dans "Uricosuriques" :
2 publications dans cette catégorie
Affiliations :
OTR3 (Organe, Tissue, Régénération, Réparation, Remplacement) Paris France.
Laboratory Cell Growth and Tissue Repair (CRRET), UPEC 4397/ERL, CNRS 9215 Université-Paris-Est-Créteil Créteil France.
Publications dans "Uricosuriques" :
2 publications dans cette catégorie
Affiliations :
Department of Medicine and Robarts Research Institute, Schulich School of Medicine, Western University, London, Ontario, Canada.
Publications dans "Uricosuriques" :
2 publications dans cette catégorie
Affiliations :
School of Statistics and Mathematics, Yunnan University of Finance and Economics, Kunming 650221, China.
Publications dans "Uricosuriques" :
2 publications dans cette catégorie
Affiliations :
Interdisciplinary Graduate School of Engineering Sciences, Kyushu University, Fukuoka 816-8580, Japan.
Faculty of Engineering Sciences, Kyushu University, Kasuga-koen, Kasuga-shi, Fukuoka 816-8580, Japan.
Publications dans "Uricosuriques" :
1 publication dans cette catégorie
Affiliations :
FUJI YAKUHIN CO., LTD. Saitama Japan.
Publications dans "Uricosuriques" :
1 publication dans cette catégorie
Affiliations :
FUJI YAKUHIN CO., LTD. Saitama Japan.
Publications dans "Uricosuriques" :
1 publication dans cette catégorie
Affiliations :
Department of Research, Clinical Trial Center Kitasato University Kitasato Institute Hospital Tokyo Japan.
Publications dans "Uricosuriques" :
1 publication dans cette catégorie
Affiliations :
FUJI YAKUHIN CO., LTD. Saitama Japan.
Publications dans "Uricosuriques" :
1 publication dans cette catégorie
Affiliations :
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, PR China.
Publications dans "Uricosuriques" :
1 publication dans cette catégorie
Affiliations :
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, PR China.
Publications dans "Uricosuriques" :
1 publication dans cette catégorie
Affiliations :
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, PR China.
Publications dans "Uricosuriques" :
1 publication dans cette catégorie
Affiliations :
Guangdong Provincial Key Laboratory of Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, PR China.
Publications dans "Uricosuriques" :
1 publication dans cette catégorie
Affiliations :
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, PR China. Electronic address: yingpeng1999@163.com.
Publications dans "Uricosuriques" :
1 publication dans cette catégorie
Affiliations :
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, PR China; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory, Guizhou Medical University, Guiyang, Guizhou 550004, PR China; Key Laboratory of Environmental Pollution, Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, 550025, PR China. Electronic address: zhengneu@yahoo.com.
Publications dans "Uricosuriques" :
Traditionally, toxic and expensive hydrazine building blocks are required to construct pharmaceutically important pyrazolidine-3,5-diones. Herein, we have described a novel method for their synthesis ...
Urate transporter 1 (URAT1) is a transporter responsible for uric acid (UA) reabsorption by renal proximal tubules and a pharmacological target of uricosuric agents. Probenecid and benzbromarone have ...
Cystic fibrosis (CF) affects multiple organs, the most severe consequences being observed in the lungs. Despite significant progress in developing CF transmembrane conductance regulator-specific treat...
This was a prospective open-label pilot study of oral benzbromarone (100 mg/day) administered once daily for 90 days. Patients were followed at a tertiary referral center in southern Brazil. Safety wa...
Ten patients were enrolled. Benzbromarone was found to be safe, with no serious drug-related adverse events. Eight patients completed the study; the median relative change in FEV1% tended to increase ...
Oral benzbromarone appears to be safe, and improved FEV1% has been observed in patients with CF. Further assessment in larger trials is warranted to elucidate whether oral benzbromarone can be a poten...
We investigated the efficacy and safety of dotinurad, a selective urate reabsorption inhibitor, in hyperuricemic patients with advanced chronic kidney disease (CKD) (stage G3-5)....
We retrospectively analyzed the cases of 34 patients (mean age, 68.6 ± 13.3 years; 17 men and 17 women) after 12 months of dotinurad treatment based on the changes in uric acid (UA) and the urine prot...
UA values decreased significantly in the dotinurad group (7.1 ± 0.8 mg/dL to 5.9 ± 1.0 mg/dL, p<0.05) but those did not change in the control group. UPCR did not change in either group. Low-density li...
Dotinurad can decrease UA levels and might attenuate renal function decline in individuals with hyperuricemia and advanced CKD....
Dotinurad is a newer urate-lowering agent that selectively inhibits urate transporter 1 in the renal proximal tubule and increases urinary urate excretion. Currently, little is known about the clinica...
This investigator-initiated, multicenter, prospective, single-arm, open-label, exploratory clinical trial in Japan enrolled patients with hyperuricemia and treated hypertension who received a 24-week ...
Fifty patients (mean age 70.5 ± 11.0 years, with 76.0% being men, and mean SUA level 8.5 ± 1.2 mg/dL) were included in the analysis. The percentage change from baseline in the SUA level at week 24 was...
In addition to meaningful SUA-lowering effects, 24 weeks of dotinurad therapy may favorably affect arterial stiffness and oxidative stress markers, suggesting off-target vascular protection of dotinur...
In this study, we aimed to clarify the beneficial effects of urate-lowering treatment with the novel agent dotinurad on renal function in patients with chronic kidney disease (CKD) and hyperuricemia (...
Thirty-five patients with CKD (mean age 65.4 ± 14.8 years, 23 men) diagnosed with HUA were recruited. Changes in eGFR before and after dotinurad administration were assessed. Patients first underwent ...
During the observation period, mean eGFR (mL/min/1.73 m...
Dotinurad administration to patients with CKD and HUA appears to be beneficial in restoring kidney function. Dotinurad may represent a potential medication for the prevention of kidney function declin...
HP501 is a highly selective renal urate transporter 1 (URAT1) inhibitor that is being developed for the treatment of hyperuricemia and gout. The primary aim of the present study was to study the pharm...
Hyperuricemic patients were randomly divided into group A, receiving HP501 40 mg once daily on days 1 and 4-10, and group B, receiving febuxostat 40 mg once daily on day 1 and HP501 40 mg plus febuxos...
Coadministration of colchicine with HP501 or HP501 plus febuxostat did not affect steady-state exposure to colchicine. Coadministration of HP501 and febuxostat did not significantly change the pharmac...
The concomitant use of HP501, febuxostat, and colchicine did not produce clinically meaningful DDIs in terms of their pharmacokinetic properties....
No. CTR20212261 ( http://www.chinadrugtrials.org.cn/ ) registered September 2021....
Hyperuricemia has become a global burden with the increasing prevalence and risk of associated metabolic disorders and cardiovascular diseases. Uricosurics act as a vital urate-lowering therapy by pro...
To determine risks associated with uricosurics in COVID-19 patients....
A systematic review and meta-analysis was conducted by systematically searching electronic databases....
The pooled analysis of the included trials revealed that the use of uricosurics was not associated with the risk of mortality (pooled odds ratio [OR] = 1.03, 95% confidence interval [CI]: 0.94-1.12). ...
The findings confirmed the safety of uricosurics in COVID-19 patients, despite their potential to cause uric acid excretion, which may possess antioxidant properties....
(1) Background: Sodium-glucose co-transporter 2 inhibitors (SGLT2is) increase uric acid excretion. The intensity of uricosuria is linked to glycosuria. (2) Methods: We aim to analyze the effect of SGL...