Mitochondrial Dysfunction and Heart Disease: Critical Appraisal of an Overlooked Association.
cardiac energetics
cardiomyopathy
heart failure
mitochondria
mitochondrial dynamics
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
09 Jan 2021
09 Jan 2021
Historique:
received:
14
12
2020
revised:
03
01
2021
accepted:
07
01
2021
entrez:
13
1
2021
pubmed:
14
1
2021
medline:
8
9
2021
Statut:
epublish
Résumé
The myocardium is among the most energy-consuming tissues in the body, burning from 6 to 30 kg of ATP per day within the mitochondria, the so-called powerhouse of the cardiomyocyte. Although mitochondrial genetic disorders account for a small portion of cardiomyopathies, mitochondrial dysfunction is commonly involved in a broad spectrum of heart diseases, and it has been implicated in the development of heart failure via maladaptive circuits producing and perpetuating mitochondrial stress and energy starvation. In this bench-to-bedside review, we aimed to (i) describe the key functions of the mitochondria within the myocardium, including their role in ischemia/reperfusion injury and intracellular calcium homeostasis; (ii) examine the contribution of mitochondrial dysfunction to multiple cardiac disease phenotypes and their transition to heart failure; and (iii) discuss the rationale and current evidence for targeting mitochondrial function for the treatment of heart failure, including via sodium-glucose cotransporter 2 inhibitors.
Identifiants
pubmed: 33435429
pii: ijms22020614
doi: 10.3390/ijms22020614
pmc: PMC7827742
pii:
doi:
Substances chimiques
Calcium
SY7Q814VUP
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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