The evaluation of pituitary damage associated with cardiac arrest: An experimental rodent model.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
12 01 2021
12 01 2021
Historique:
received:
09
05
2020
accepted:
24
11
2020
entrez:
13
1
2021
pubmed:
14
1
2021
medline:
11
8
2021
Statut:
epublish
Résumé
The pituitary gland plays an important endocrinal role, however its damage after cardiac arrest (CA) has not been well elucidated. The aim of this study was to determine a pituitary gland damage induced by CA. Rats were subjected to 10-min asphyxia and cardiopulmonary resuscitation (CPR). Immunohistochemistry and ELISA assays were used to evaluate the pituitary damage and endocrine function. Samples were collected at pre-CA, and 30 and 120 min after cardio pulmonary resuscitation. Triphenyltetrazolium chloride (TTC) staining demonstrated the expansion of the pituitary damage over time. There was phenotypic validity between the pars distalis and nervosa. Both CT-proAVP (pars nervosa hormone) and GH/IGF-1 (pars distalis hormone) decreased over time, and a different expression pattern corresponding to the damaged areas was noted (CT-proAVP, 30.2 ± 6.2, 31.5 ± 5.9, and 16.3 ± 7.6 pg/mg protein, p < 0.01; GH/IGF-1, 2.63 ± 0.61, 0.62 ± 0.36, and 2.01 ± 0.41 ng/mg protein, p < 0.01 respectively). Similarly, the expression pattern between these hormones in the end-organ systems showed phenotypic validity. Plasma CT-proAVP (r = 0.771, p = 0.025) and IGF-1 (r = -0.775, p = 0.024) demonstrated a strong correlation with TTC staining area. Our data suggested that CA induces pathological and functional damage to the pituitary gland.
Identifiants
pubmed: 33436714
doi: 10.1038/s41598-020-79780-3
pii: 10.1038/s41598-020-79780-3
pmc: PMC7804952
doi:
Substances chimiques
Biomarkers
0
HMGB1 Protein
0
Hbp1 protein, rat
0
Slc5a2 protein, rat
0
Sodium-Glucose Transporter 2
0
Types de publication
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
629Références
J Cardiovasc Thorac Res. 2016;8(2):61-4
pubmed: 27489598
Stroke. 1986 Nov-Dec;17(6):1304-8
pubmed: 2433817
Diab Vasc Dis Res. 2019 Jan;16(1):22-27
pubmed: 30309264
Vnitr Lek. 2016 Fall;62(11 Suppl 4):S62-66
pubmed: 27921427
Epilepsia. 2019 Feb;60(2):201-210
pubmed: 30645779
Endocrinol Metab (Seoul). 2015 Dec;30(4):443-55
pubmed: 26790380
World J Crit Care Med. 2012 Feb 04;1(1):4-9
pubmed: 24701395
Respir Med. 2012 Sep;106(9):1268-77
pubmed: 22728017
Front Cell Neurosci. 2018 Jan 19;12:2
pubmed: 29403357
Crit Care Med. 2004 Sep;32(9 Suppl):S432-5
pubmed: 15508673
Crit Care. 2016 Apr 03;20:82
pubmed: 27038920
Crit Care Med. 1993 Sep;21(9):1339-47
pubmed: 8396524
Circulation. 2008 Dec 2;118(23):2452-83
pubmed: 18948368
Neurosci Lett. 2013 Oct 25;554:156-61
pubmed: 24016413
Shock. 2004 Aug;22(2):116-9
pubmed: 15257083
Curr Opin Nephrol Hypertens. 2015 Sep;24(5):463-9
pubmed: 26125647
Resuscitation. 2014 Jul;85(7):964-71
pubmed: 24727136
Resuscitation. 2004 Jul;62(1):55-60
pubmed: 15246584
Eur J Biochem. 1972 Jul 24;28(3):334-9
pubmed: 5079944
Crit Care. 2015 Mar 31;19:132
pubmed: 25886856
Indian J Endocrinol Metab. 2011 Sep;15 Suppl 3:S188-96
pubmed: 22029023
Peptides. 2005 Dec;26(12):2500-4
pubmed: 15922490
J Cereb Blood Flow Metab. 2009 Oct;29(10):1673-82
pubmed: 19553908
Neuroendocrinology. 1983 May;36(5):376-84
pubmed: 6406927
J Cereb Blood Flow Metab. 2020 Aug 12;:271678X20948612
pubmed: 32787543
FASEB J. 2007 Dec;21(14):3904-16
pubmed: 17628015
Circulation. 2015 Nov 3;132(18 Suppl 2):S465-82
pubmed: 26472996
Intensive Care Med Exp. 2019 Dec 2;7(1):62
pubmed: 31792731
Crit Care. 2004 Feb;8(1):15-23
pubmed: 14975041
J Cardiovasc Thorac Res. 2012;4(4):107-11
pubmed: 24250997
World Neurosurg. 2019 Feb;122:e864-e871
pubmed: 30391757
Front Endocrinol (Lausanne). 2011 Aug 25;2:25
pubmed: 22649368
Radiology. 1998 Apr;207(1):79-83
pubmed: 9530302
Resuscitation. 2008 Dec;79(3):350-79
pubmed: 18963350
Crit Care Med. 2010 Oct;38(10):1962-9
pubmed: 20639747
Alcohol Health Res World. 1998;22(3):153-64
pubmed: 15706790
Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3507-12
pubmed: 23401516
Ann Neurol. 2012 Sep;72(3):373-84
pubmed: 22915134
Eur Heart J. 2009 May;30(10):1187-94
pubmed: 19346228
J Vet Med A Physiol Pathol Clin Med. 2007 Jun;54(5):260-4
pubmed: 17523961
Clin Chem. 2006 Jan;52(1):112-9
pubmed: 16269513
Interdiscip Inf Sci. 2015;21(3):225-234
pubmed: 28035187
Endocrine. 2017 Sep;57(3):474-480
pubmed: 28795329
Biomark Med. 2014;8(6):841-54
pubmed: 25224940
Crit Care Med. 2018 Jun;46(6):e508-e515
pubmed: 29533310
PLoS One. 2019 Jul 30;14(7):e0220467
pubmed: 31361786
Horm Behav. 2014 Mar;65(3):273-84
pubmed: 24444675