Circulating microRNA: The Potential Novel Diagnostic Biomarkers to Predict Drug Resistance in Temporal Lobe Epilepsy, a Pilot Study.
ASMs
antiseizure medications
diagnosis
miRNAs
prognosis
temporal lobe epilepsy
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Jan 2021
12 Jan 2021
Historique:
received:
22
12
2020
revised:
06
01
2021
accepted:
10
01
2021
entrez:
15
1
2021
pubmed:
16
1
2021
medline:
7
4
2021
Statut:
epublish
Résumé
MicroRNAs (miRNAs) are small noncoding RNAs that have emerged as new potential epigenetic biomarkers. Here, we evaluate the efficacy of six circulating miRNA previously described in the literature as biomarkers for the diagnosis of temporal lobe epilepsy (TLE) and/or as predictive biomarkers to antiepileptic drug response. We measured the differences in serum miRNA levels by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) assays in a cohort of 27 patients (14 women and 13 men; mean ± SD age: 43.65 ± 17.07) with TLE compared to 20 healthy controls (HC) matched for sex, age and ethnicity (11 women and 9 men; mean ± SD age: 47.5 ± 9.1). Additionally, patients were classified according to whether they had drug-responsive (
Identifiants
pubmed: 33445780
pii: ijms22020702
doi: 10.3390/ijms22020702
pmc: PMC7828221
pii:
doi:
Substances chimiques
Biomarkers
0
Circulating MicroRNA
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Italian Ministry of Education, University and Research (MIUR) [L.232/2016]. INTEROMICS flagship project (Interomics PB05), National Research Council CUP
ID : Grant B91JI2000190001
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