Effect of Capsaicinoids on Neurophysiological, Biochemical, and Mechanical Parameters of Swallowing Function.
Adult
Biomechanical Phenomena
Capsaicin
/ analogs & derivatives
Cerebral Cortex
/ diagnostic imaging
Deglutition
/ drug effects
Electromyography
Esophageal Sphincter, Upper
/ drug effects
Female
Healthy Volunteers
Humans
Magnetoencephalography
Male
Manometry
Pharynx
/ drug effects
Random Allocation
Saliva
/ chemistry
Sensory System Agents
/ pharmacology
Substance P
/ drug effects
Young Adult
Capsaicin
Deglutition disorders
Dysphagia
Substance P
Swallowing
Journal
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
ISSN: 1878-7479
Titre abrégé: Neurotherapeutics
Pays: United States
ID NLM: 101290381
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
accepted:
17
12
2020
pubmed:
16
1
2021
medline:
1
2
2022
entrez:
15
1
2021
Statut:
ppublish
Résumé
Oropharyngeal dysphagia is prevalent in age-related neurological disorders presenting with impaired efficacy and safety of swallowing due to a loss of muscle force and sensory deficits. Stimulating the oropharynx with capsaicin that mediates Substance P release is an emerging pharmacological treatment option which needs further scientific evidence. Our aim was to comprehensively evaluate the effect of capsaicin on biochemical, neurophysiological, and biomechanical parameters of swallowing function. In a randomized study on healthy individuals, the impact of orally administered capsaicinoids at different dosages and application durations in comparison to non-carbonated water was evaluated. Time course and magnitude of salivary Substance P increase were monitored. Magnetoencephalography was used to detect cortical swallowing network alterations. Modifications in swallowing biomechanics were measured applying high-resolution pharyngeal manometry. Capsaicinoids at 10 μmol/L improved swallowing efficacy as seen by a significant increase of pharyngeal contractile integral and upper esophageal sphincter activation and relaxation times in manometry. Significant improvement of precision in a challenging swallow task accompanied by a reduction in swallowing-related submental electromyographic power was observed with capsaicinoids preconditioning at 10 μmol/L over 5 min, but not with continuous stimulation. The cortical activation pattern remained unchanged after any intervention. A significant increase of salivary Substance P was not detected with 10 μmol/L but with 50 μmol/L and lasted for 15 min after application. Capsaicinoids mediate dose-dependent Substance P release and positively alter swallowing biomechanics in healthy subjects. The results provide supportive evidence for the value of natural capsaicinoids to improve swallowing function.
Identifiants
pubmed: 33449304
doi: 10.1007/s13311-020-00996-2
pii: 10.1007/s13311-020-00996-2
pmc: PMC8423940
doi:
Substances chimiques
Sensory System Agents
0
Substance P
33507-63-0
nordihydrocapsaicin
RF657P8DA8
Capsaicin
S07O44R1ZM
dihydrocapsaicin
W9BV32M08A
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1360-1370Informations de copyright
© 2021. The Author(s).
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