A basophil-neuronal axis promotes itch.

Acute Disease Allergens / immunology Animals Basophils / pathology Chronic Disease Dermatitis, Atopic / immunology Disease Models, Animal Histamine / metabolism Humans Immunoglobulin E / immunology Inflammation / pathology Leukotrienes / metabolism Mast Cells / immunology Mice, Inbred C57BL Neurons / pathology Phenotype Pruritus / immunology TRPA1 Cation Channel / metabolism TRPV Cation Channels / metabolism
IgE allergy atopic dermatitis basophils itch leukotriene mast cells pruritus sensory neurons

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
21 01 2021
Historique:
received: 21 05 2020
revised: 09 10 2020
accepted: 21 12 2020
pubmed: 16 1 2021
medline: 27 8 2021
entrez: 15 1 2021
Statut: ppublish

Résumé

Itch is an evolutionarily conserved sensation that facilitates expulsion of pathogens and noxious stimuli from the skin. However, in organ failure, cancer, and chronic inflammatory disorders such as atopic dermatitis (AD), itch becomes chronic, intractable, and debilitating. In addition to chronic itch, patients often experience intense acute itch exacerbations. Recent discoveries have unearthed the neuroimmune circuitry of itch, leading to the development of anti-itch treatments. However, mechanisms underlying acute itch exacerbations remain overlooked. Herein, we identify that a large proportion of patients with AD harbor allergen-specific immunoglobulin E (IgE) and exhibit a propensity for acute itch flares. In mice, while allergen-provoked acute itch is mediated by the mast cell-histamine axis in steady state, AD-associated inflammation renders this pathway dispensable. Instead, a previously unrecognized basophil-leukotriene (LT) axis emerges as critical for acute itch flares. By probing fundamental itch mechanisms, our study highlights a basophil-neuronal circuit that may underlie a variety of neuroimmune processes.

Identifiants

DOI: 10.1016/j.cell.2020.12.033 PMID: 33450207 PMC: PMC7878015
pubmed: 33450207
pii: S0092-8674(20)31755-4
doi: 10.1016/j.cell.2020.12.033
pmc: PMC7878015
mid: NIHMS1660838
pii:
doi:

Substances chimiques

Allergens 0
Leukotrienes 0
TRPA1 Cation Channel 0
TRPV Cation Channels 0
TRPV1 protein, mouse 0
Trpa1 protein, mouse 0
Immunoglobulin E 37341-29-0
Histamine 820484N8I3

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

422-440.e17

Subventions

Organisme : NIAMS NIH HHS
ID : K08 AR065577
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR070116
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR056755
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS054791
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA027065
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI077600
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA091842
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK103901
Pays : United States
Organisme : NIAID NIH HHS
ID : F30 AI154912
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR070873
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR069062
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG060962
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : CommentIn
Type : CommentIn

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests B.S.K. has served as a consultant for AbbVie, ABRAX Japan, Almirall, AstraZeneca, Cara Therapeutics, Daewoong Pharmaceutical, Incyte, LEO Pharma, Lilly, Maruho, Menlo Therapeutics, OM Pharma, Pfizer, and Third Rock Ventures. He has also participated on the advisory board for Almirall, Boehringer Ingelheim, Cara Therapeutics, Kiniksa Pharmaceuticals, Menlo Therapeutics, Regeneron Pharmaceuticals, Sanofi Genzyme, and Trevi Therapeutics. He is stockholder of Locus Biosciences. All other authors declare that they have no relevant conflicts of interest.

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Auteurs

Fang Wang (F)

Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for the Study of Itch and Sensory Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.

Anna M Trier (AM)

Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for the Study of Itch and Sensory Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.

Fengxian Li (F)

Center for the Study of Itch and Sensory Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Anesthesiology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong 510282, China; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Seonyoung Kim (S)

Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

Zhen Chen (Z)

Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.

Jiani N Chai (JN)

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Madison R Mack (MR)

Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for the Study of Itch and Sensory Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.

Stephanie A Morrison (SA)

Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for the Study of Itch and Sensory Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.

Jennifer D Hamilton (JD)

Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.

Jinok Baek (J)

Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Dermatology, College of Medicine, Gachon University, Incheon 21565, Korea.

Ting-Lin B Yang (TB)

Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for the Study of Itch and Sensory Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.

Aaron M Ver Heul (AM)

Center for the Study of Itch and Sensory Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

Amy Z Xu (AZ)

Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for the Study of Itch and Sensory Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.

Zili Xie (Z)

Center for the Study of Itch and Sensory Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Xintong Dong (X)

The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Masato Kubo (M)

Laboratory for Cytokine Regulation, Center for Integrative Medical Science, RIKEN Yokohama Institute, Yokohama 230-0045, Kanagawa Prefecture, Japan; Division of Molecular Pathology, Research Institute for Biomedical Science, Tokyo University of Science, Noda 278-0022, Chiba Prefecture, Japan.

Hongzhen Hu (H)

Center for the Study of Itch and Sensory Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Chyi-Song Hsieh (CS)

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Division of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

Xinzhong Dong (X)

The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Qin Liu (Q)

Center for the Study of Itch and Sensory Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

David J Margolis (DJ)

Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

Marius Ardeleanu (M)

Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.

Mark J Miller (MJ)

Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

Brian S Kim (BS)

Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for the Study of Itch and Sensory Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: briankim@wustl.edu.

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Classifications MeSH

questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie aigüe › A basophil-neuronal axis promotes itch.
questionsmedicales.fr › Facteurs biologiques › Antigènes › Allergènes › A basophil-neuronal axis promotes itch.
questionsmedicales.fr › Eucaryotes › Animaux › A basophil-neuronal axis promotes itch.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Granulocytes › Granulocytes basophiles › A basophil-neuronal axis promotes itch.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › A basophil-neuronal axis promotes itch.
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Eczéma atopique › A basophil-neuronal axis promotes itch.
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › A basophil-neuronal axis promotes itch.
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Histamine › A basophil-neuronal axis promotes itch.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A basophil-neuronal axis promotes itch.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline E › A basophil-neuronal axis promotes itch.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › A basophil-neuronal axis promotes itch.
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Leucotriènes › A basophil-neuronal axis promotes itch.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Mastocytes › A basophil-neuronal axis promotes itch.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › A basophil-neuronal axis promotes itch.
questionsmedicales.fr › Cellules › Neurones › A basophil-neuronal axis promotes itch.
questionsmedicales.fr › Phénomènes génétiques › Phénotype › A basophil-neuronal axis promotes itch.
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations cutanées › Prurit › A basophil-neuronal axis promotes itch.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux cationiques TRP › Membre-1 de la sous-famille A de canaux cationiques à potentiel de récepteur transitoire › A basophil-neuronal axis promotes itch.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Canaux cationiques TRPV › A basophil-neuronal axis promotes itch.