Monitoring Lipophilic Toxins in Seawater Using Dispersive Liquid-Liquid Microextraction and Liquid Chromatography with Triple Quadrupole Mass Spectrometry.
dispersive liquid–liquid microextraction
lipophilic marine toxins
liquid chromatography
seawater
triple quadrupole tandem mass spectrometry
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
13 01 2021
13 01 2021
Historique:
received:
25
11
2020
revised:
07
01
2021
accepted:
09
01
2021
entrez:
16
1
2021
pubmed:
17
1
2021
medline:
22
7
2021
Statut:
epublish
Résumé
The use of dispersive liquid-liquid microextraction (DLLME) is proposed for the preconcentration of thirteen lipophilic marine toxins in seawater samples. For this purpose, 0.5 mL of methanol and 440 µL of chloroform were injected into 12 mL of sample. The enriched organic phase, once evaporated and reconstituted in methanol, was analyzed by reversed-phase liquid chromatography with triple-quadrupole tandem mass spectrometry. A central composite design multivariate method was used to optimize the interrelated parameters affecting DLLME efficiency. The absence of any matrix effect in the samples allowed them to be quantified against aqueous standards. The optimized procedure was validated by recovery studies, which provided values in the 82-123% range. The detection limits varied between 0.2 and 5.7 ng L
Identifiants
pubmed: 33451113
pii: toxins13010057
doi: 10.3390/toxins13010057
pmc: PMC7828625
pii:
doi:
Substances chimiques
Marine Toxins
0
Chloroform
7V31YC746X
Methanol
Y4S76JWI15
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fundación Séneca, Spain
ID : 19888/GERM/15
Organisme : Ministry of Science
ID : PGC2018-098363-B-100
Références
J Chromatogr A. 2009 May 22;1216(21):4529-38
pubmed: 19362722
Sci Total Environ. 2019 May 1;663:901-914
pubmed: 30738269
Food Chem. 2019 Jan 30;272:427-433
pubmed: 30309565
Chemosphere. 2017 Feb;168:32-40
pubmed: 27776236
Harmful Algae. 2017 Apr;64:30-41
pubmed: 28427570
Toxins (Basel). 2019 Mar 29;11(4):
pubmed: 30934968
J Chromatogr A. 2014 Feb 7;1328:16-25
pubmed: 24444801
Toxins (Basel). 2019 Oct 22;11(10):
pubmed: 31652586
Environ Sci Pollut Res Int. 2015 Feb;22(4):3116-26
pubmed: 25233922
Sci Total Environ. 2018 Jan 15;612:931-939
pubmed: 28886545
Mar Pollut Bull. 2015 Dec 30;101(2):954-60
pubmed: 26507511
Environ Sci Pollut Res Int. 2019 May;26(14):14266-14276
pubmed: 30864033
J AOAC Int. 1995 Mar-Apr;78(2):555-70
pubmed: 7756869
J Chromatogr A. 2002 Jul 19;963(1-2):353-61
pubmed: 12187990
Talanta. 2018 Nov 1;189:622-628
pubmed: 30086968
Anal Bioanal Chem. 2010 Jul;397(5):1653-4
pubmed: 20496031
Mar Drugs. 2018 Jan 31;16(2):
pubmed: 29385038
Anal Bioanal Chem. 2008 Nov;392(5):797-803
pubmed: 18584156
Food Chem. 2011 Nov 15;129(2):533-540
pubmed: 30634263
Anal Bioanal Chem. 2009 Jun;394(4):1213-26
pubmed: 19387619
Mar Drugs. 2015 Jul 14;13(7):4281-95
pubmed: 26184236
Anal Bioanal Chem. 2017 Sep;409(23):5451-5462
pubmed: 28815284
Chemosphere. 2017 Sep;183:380-388
pubmed: 28554022
J AOAC Int. 2014 Mar-Apr;97(2):316-24
pubmed: 24830142
Anal Bioanal Chem. 2015 Aug;407(21):6345-56
pubmed: 25893798
Harmful Algae. 2016 May;55:112-120
pubmed: 28073524
Toxicon. 2016 May;114:16-27
pubmed: 26896635
Food Addit Contam. 1999 Jun;16(6):239-51
pubmed: 10560577
J Chromatogr A. 2007 Jul 20;1157(1-2):273-80
pubmed: 17521661
Talanta. 2013 Nov 15;116:770-5
pubmed: 24148472
Chemosphere. 2014 Sep;111:560-7
pubmed: 24997966
Food Chem. 2019 Oct 1;294:104-111
pubmed: 31126442
Anal Bioanal Chem. 2010 Jul;397(5):1715-22
pubmed: 20446082