Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis.
Amino Acid Motifs
Arabidopsis
/ physiology
Arabidopsis Proteins
/ genetics
Crystallography, X-Ray
Diphosphates
/ metabolism
Gene Expression Regulation, Plant
Inositol Phosphates
/ metabolism
Mutation
Nuclear Proteins
/ genetics
Protein Binding
/ genetics
Protein Domains
/ genetics
Recombinant Proteins
/ genetics
Signal Transduction
/ genetics
Transcription Factors
/ genetics
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
15 01 2021
15 01 2021
Historique:
received:
13
12
2019
accepted:
09
12
2020
entrez:
16
1
2021
pubmed:
17
1
2021
medline:
30
1
2021
Statut:
epublish
Résumé
Phosphorus is an essential nutrient taken up by organisms in the form of inorganic phosphate (Pi). Eukaryotes have evolved sophisticated Pi sensing and signaling cascades, enabling them to stably maintain cellular Pi concentrations. Pi homeostasis is regulated by inositol pyrophosphate signaling molecules (PP-InsPs), which are sensed by SPX domain-containing proteins. In plants, PP-InsP-bound SPX receptors inactivate Myb coiled-coil (MYB-CC) Pi starvation response transcription factors (PHRs) by an unknown mechanism. Here we report that a InsP
Identifiants
pubmed: 33452263
doi: 10.1038/s41467-020-20681-4
pii: 10.1038/s41467-020-20681-4
pmc: PMC7810988
doi:
Substances chimiques
Arabidopsis Proteins
0
Diphosphates
0
Inositol Phosphates
0
Nuclear Proteins
0
PHR1 protein, Arabidopsis
0
Recombinant Proteins
0
SPX1 protein, Arabidopsis
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
384Subventions
Organisme : Howard Hughes Medical Institute
Pays : United States
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