Thiophen urea derivatives as a new class of hepatitis C virus entry inhibitors.
Antiviral Agents
/ chemical synthesis
Dose-Response Relationship, Drug
Hepacivirus
/ drug effects
Microbial Sensitivity Tests
Molecular Docking Simulation
Molecular Structure
Structure-Activity Relationship
Thiophenes
/ chemical synthesis
Urea
/ analogs & derivatives
Viral Envelope Proteins
/ antagonists & inhibitors
Virus Internalization
/ drug effects
Entry inhibitor
hepatitis C virus
small molecule
thiophen urea
Journal
Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
entrez:
18
1
2021
pubmed:
19
1
2021
medline:
25
6
2021
Statut:
ppublish
Résumé
To develop unique small-molecule inhibitors of hepatitis C virus (HCV), thiophen urea (TU) derivatives were synthesised and screened for HCV entry inhibitory activities. Among them, seven TU compounds exhibited portent anti-viral activities against genotypes 1/2 (EC
Identifiants
pubmed: 33455472
doi: 10.1080/14756366.2020.1870456
pmc: PMC7822064
doi:
Substances chimiques
Antiviral Agents
0
Thiophenes
0
Viral Envelope Proteins
0
glycoprotein E2, Hepatitis C virus
157184-61-7
Urea
8W8T17847W
Types de publication
Journal Article
Retracted Publication
Langues
eng
Sous-ensembles de citation
IM
Pagination
462-468Commentaires et corrections
Type : RetractionIn
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