Novel compounds with dual S1P receptor agonist and histamine H

Animals CHO Cells Cricetinae Cricetulus Encephalomyelitis, Autoimmune, Experimental / metabolism Female Fingolimod Hydrochloride / administration & dosage Histamine H3 Antagonists / administration & dosage Mice Mice, Inbred C57BL Mice, Transgenic Multiple Sclerosis / metabolism Neuroprotective Agents / administration & dosage Protein Structure, Secondary Sphingosine-1-Phosphate Receptors / agonists
EAE H(3)R Histamine Multiple sclerosis Pitolisant ST-1478 ST-1505 Sphingosine 1-phosphate

Journal

Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217

Informations de publication

Date de publication:
15 03 2021
Historique:
received: 25 09 2020
revised: 22 12 2020
accepted: 11 01 2021
pubmed: 19 1 2021
medline: 6 11 2021
entrez: 18 1 2021
Statut: ppublish

Résumé

The sphingosine 1-phosphate (S1P) receptor 1 (S1P

Identifiants

DOI: 10.1016/j.neuropharm.2021.108464 PMID: 33460688
pubmed: 33460688
pii: S0028-3908(21)00018-6
doi: 10.1016/j.neuropharm.2021.108464
pii:
doi:

Substances chimiques

Histamine H3 Antagonists 0
Neuroprotective Agents 0
Sphingosine-1-Phosphate Receptors 0
Fingolimod Hydrochloride G926EC510T

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108464

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Faik Imeri (F)

Institute of Pharmacology, University of Bern, Inselspital INO-F, CH-3010, Bern, Switzerland.

Bisera Stepanovska Tanturovska (B)

Institute of Pharmacology, University of Bern, Inselspital INO-F, CH-3010, Bern, Switzerland.

Aleksandra Zivkovic (A)

Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr. 1, D-40225, Duesseldorf, Germany.

Gaby Enzmann (G)

Theodor Kocher Institute, University of Bern, Freiestrasse 1, CH-3012, Bern, Switzerland.

Stephanie Schwalm (S)

Pharmazentrum Frankfurt/ZAFES, University Hospital, Goethe University Frankfurt am Main, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany.

Josef Pfeilschifter (J)

Pharmazentrum Frankfurt/ZAFES, University Hospital, Goethe University Frankfurt am Main, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany.

Thomas Homann (T)

Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert Allee 114-116, D-14558, Nuthetal, Germany.

Burkhard Kleuser (B)

Institute of Pharmacy, Department of Pharmacology and Toxicology, Freie Universität Berlin, Königin-Luise-Str. 2+4, D-14195, Berlin, Germany.

Britta Engelhardt (B)

Theodor Kocher Institute, University of Bern, Freiestrasse 1, CH-3012, Bern, Switzerland.

Holger Stark (H)

Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr. 1, D-40225, Duesseldorf, Germany. Electronic address: stark@hhu.de.

Andrea Huwiler (A)

Institute of Pharmacology, University of Bern, Inselspital INO-F, CH-3010, Bern, Switzerland. Electronic address: Huwiler@pki.unibe.ch.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Novel compounds with dual S1P receptor agonist...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules CHO › Novel compounds with dual S1P receptor agonist...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › Novel compounds with dual S1P receptor agonist...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › Cricetulus › Novel compounds with dual S1P receptor agonist...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Maladie neurologique auto-immune expérimentale › Encéphalomyélite auto-immune expérimentale › Novel compounds with dual S1P receptor agonist...
questionsmedicales.fr › Composés chimiques organiques › Amines › Aminoalcools › Sphingosine › Chlorhydrate de fingolimod › Novel compounds with dual S1P receptor agonist...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents histaminiques › Antihistaminiques › Antihistaminiques des récepteurs H3 › Novel compounds with dual S1P receptor agonist...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Novel compounds with dual S1P receptor agonist...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Novel compounds with dual S1P receptor agonist...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Novel compounds with dual S1P receptor agonist...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Novel compounds with dual S1P receptor agonist...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Neuroprotecteurs › Novel compounds with dual S1P receptor agonist...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure secondaire des protéines › Novel compounds with dual S1P receptor agonist...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs aux lysophospholipides › Récepteurs aux lysosphingolipides › Récepteurs de la sphingosine-1-phosphate › Novel compounds with dual S1P receptor agonist...