Gastrointestinal Zygomycosis in a Preterm Neonate Associated With Contaminated Probiotics.


Journal

The Pediatric infectious disease journal
ISSN: 1532-0987
Titre abrégé: Pediatr Infect Dis J
Pays: United States
ID NLM: 8701858

Informations de publication

Date de publication:
01 04 2021
Historique:
pubmed: 20 1 2021
medline: 27 11 2021
entrez: 19 1 2021
Statut: ppublish

Résumé

A neonate of 29 weeks' gestation who received probiotics developed clinical signs suggesting surgical necrotizing enterocolitis. A specimen of resected ileum revealed fungal forms within the bowel wall. Rhizopus oryzae was detected via DNA sequencing from probiotic powder and tissue specimens from the infant. To our knowledge, this is the first report linking gastrointestinal zygomycosis to the administration of contaminated probiotics.

Identifiants

pubmed: 33464011
doi: 10.1097/INF.0000000000003063
pii: 00006454-202104000-00024
doi:

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

365-367

Informations de copyright

Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

Déclaration de conflit d'intérêts

The authors have no funding or conflicts of interest to disclose.

Références

Roilides E, Zaoutis TE, Katragkou A, et al.Zygomycosis in neonates: an uncommon but life-threatening infection. Am J Perinatol.2009; 26:565–573
Inoue S, Odaka A, Hashimoto D, et al.Rare case of disseminated neonatal zygomycosis mimicking necrotizing enterocolitis with necrotizing fasciitis. J Pediatr Surg.2011; 46:E29–E32
Jensen HE, Aalbaek B, Lind P, et al.Immunohistochemical diagnosis of systemic bovine zygomycosis by murine monoclonal antibodies. Vet Pathol.1996; 33:176–183
Balajee SA, Lindsley MD, Iqbal N, et al.Nonsporulating clinical isolate identified as Petromyces alliaceus (anamorph Aspergillus alliaceus ) by morphological and sequence-based methods. J Clin Microbiol.2007; 45:2701–2703
Muñoz-Cadavid C, Rudd S, Zaki SR, et al.Improving molecular detection of fungal DNA in formalin-fixed paraffin-embedded tissues: comparison of five tissue DNA extraction methods using panfungal PCR. J Clin Microbiol.2010; 48:2147–2153
United States Food and Drug Administration. Dietary supplements containing live bacteria or yeast in immunocompromised persons: warning - risk of invasive fungal disease. Available at: https://wayback.archive-it.org/7993/20170406123959/https://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm426331.htm . Accessed August 24, 2020
Vallabhaneni S, Walker TA, Lockhart SR, et al.; Centers for Disease Control and Prevention. Notes from the field: fatal gastrointestinal mucormycosis in a premature infant associated with a contaminated dietary supplement-Connecticut 2014. MMWR Morbid Mortal Wkly Rep. 2015; 65:155–156
United States Food and Drug Administration. Current good manufacturing practice in manufacturing, packaging, labeling, or holding operations for dietary supplements. Available at: https://www.ecfr.gov/cgi-bin/text-idx?SID=3f7125891958b3eb9380856f26065b5c&mc=true&node=pt21.2.111&rgn=div5 . Accessed August 20, 2020
Yousuf EI, Carvalho M, Dizzell SE, et al.Persistence of suspected probiotic organisms in preterm infant gut microbiota weeks after probiotic supplementation in the NICU. Front Microbiol.2020; 11:574137
Sharif S, Meader N, Oddie SJ, et al.Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants. Cochrane Database Syst Rev.2020; 10:CD005496

Auteurs

Matthew J Bizzarro (MJ)

From the Department of Pediatrics.

David R Peaper (DR)

Department of Laboratory Medicine.

Raffaella A Morotti (RA)

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.

George Paci (G)

Infection Control and Hospital Epidemiology.

Michelle Rychalsky (M)

Pharmacy Services, Yale-New Haven Hospital, New Haven, Connecticut.

John M Boyce (JM)

Pharmacy Services, Yale-New Haven Hospital, New Haven, Connecticut.
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.

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Classifications MeSH